LIF [The Human Chemical-Genetic Interaction Map Project]

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======= LIF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIF
  * **<color #00a2e8>Official Name</color>**: LIF interleukin 6 family cytokine
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3976|3976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15018|P15018]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIF OSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H3-K27 acetylation|
|regulation of histone H3-K27 acetylation|
|leukemia inhibitory factor receptor binding|
|spongiotrophoblast differentiation|
|leukemia inhibitory factor signaling pathway|
|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|lung vasculature development|
|lung lobe morphogenesis|
|regulation of metanephric nephron tubule epithelial cell differentiation|
|lung lobe development|
|positive regulation of epithelial cell differentiation involved in kidney development|
|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|tyrosine phosphorylation of STAT protein|
|negative regulation of meiotic nuclear division|
|spongiotrophoblast layer development|
|trophoblast giant cell differentiation|
|positive regulation of astrocyte differentiation|
|regulation of nephron tubule epithelial cell differentiation|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|positive regulation of macrophage differentiation|
|positive regulation of metanephros development|
|negative regulation of meiotic cell cycle|
|regulation of epithelial cell differentiation involved in kidney development|
|positive regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of macrophage differentiation|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|regulation of metanephros development|
|decidualization|
|cell differentiation involved in embryonic placenta development|
|regulation of astrocyte differentiation|
|positive regulation of histone acetylation|
|regulation of meiotic nuclear division|
|blood vessel remodeling|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of morphogenesis of an epithelium|
|maternal placenta development|
|embryo implantation|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|positive regulation of kidney development|
|lung alveolus development|
|positive regulation of protein acetylation|
|positive regulation of glial cell differentiation|
|lung morphogenesis|
|negative regulation of nuclear division|
|regulation of meiotic cell cycle|
|regulation of transcription regulatory region DNA binding|
|positive regulation of myeloid leukocyte differentiation|
|regulation of kidney development|
|regulation of histone acetylation|
|negative regulation of reproductive process|
|positive regulation of epithelial cell differentiation|
|regulation of peptidyl-lysine acetylation|
|negative regulation of hormone secretion|
|maternal process involved in female pregnancy|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|regulation of protein acetylation|
|positive regulation of protein localization to nucleus|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of animal organ morphogenesis|
|positive regulation of receptor signaling pathway via JAK-STAT|
|muscle organ morphogenesis|
|embryonic placenta development|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of histone modification|
|positive regulation of myeloid cell differentiation|
|tissue remodeling|
|positive regulation of chromatin organization|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of myeloid leukocyte differentiation|
|regulation of gliogenesis|
|regulation of protein localization to nucleus|
|regulation of DNA binding|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|stem cell population maintenance|
|regulation of peptidyl-serine phosphorylation|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|peptidyl-tyrosine phosphorylation|
|regulation of histone modification|
|peptidyl-tyrosine modification|
|positive regulation of leukocyte differentiation|
|placenta development|
|stem cell differentiation|
|regulation of reproductive process|
|growth factor activity|
|negative regulation of MAPK cascade|
|lung development|
|respiratory tube development|
|cytokine activity|
|positive regulation of chromosome organization|
|regulation of morphogenesis of an epithelium|
|female pregnancy|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|respiratory system development|
|negative regulation of secretion by cell|
|multi-multicellular organism process|
|regulation of myeloid cell differentiation|
|negative regulation of secretion|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|regulation of hormone secretion|
|regulation of leukocyte differentiation|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|signaling receptor binding|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of binding|
|in utero embryonic development|
|negative regulation of protein phosphorylation|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|muscle structure development|
|negative regulation of transport|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|regulation of hormone levels|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6641
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIF Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>