LILRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= LILRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LILRB2
  * **<color #00a2e8>Official Name</color>**: leukocyte immunoglobulin like receptor B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10288|10288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N423|Q8N423]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LILRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LILRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604815|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of postsynaptic density organization|
|inhibitory MHC class I receptor activity|
|MHC class Ib protein complex binding|
|Fc receptor mediated inhibitory signaling pathway|
|MHC class Ib protein binding|
|positive regulation of T cell tolerance induction|
|immune response-inhibiting cell surface receptor signaling pathway|
|positive regulation of long-term synaptic depression|
|immune response-inhibiting signal transduction|
|regulation of T cell tolerance induction|
|negative regulation of antigen processing and presentation|
|positive regulation of tolerance induction|
|regulation of dendritic cell differentiation|
|positive regulation of regulatory T cell differentiation|
|regulation of long-term synaptic depression|
|regulation of postsynaptic density organization|
|regulation of tolerance induction|
|MHC class I protein binding|
|protein phosphatase 1 binding|
|regulation of antigen processing and presentation|
|negative regulation of synapse organization|
|regulation of regulatory T cell differentiation|
|heterotypic cell-cell adhesion|
|positive regulation of protein dephosphorylation|
|regulation of long-term synaptic potentiation|
|cellular defense response|
|cell adhesion molecule binding|
|positive regulation of dephosphorylation|
|negative regulation of T cell proliferation|
|negative regulation of calcium ion transport|
|ficolin-1-rich granule membrane|
|tertiary granule membrane|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|amyloid-beta binding|
|positive regulation of T cell differentiation|
|positive regulation of lymphocyte differentiation|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|regulation of postsynapse organization|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of interleukin-6 production|
|regulation of protein dephosphorylation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of ion transport|
|regulation of T cell proliferation|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|regulation of synaptic plasticity|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of dephosphorylation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of synapse organization|
|regulation of leukocyte proliferation|
|regulation of synapse structure or activity|
|regulation of calcium ion transport|
|positive regulation of cell-cell adhesion|
|learning or memory|
|protein-containing complex binding|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|cognition|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|positive regulation of lymphocyte activation|
|negative regulation of organelle organization|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|behavior|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|leukocyte mediated immunity|
|exocytosis|
|response to lipid|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|positive regulation of cell differentiation|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LILRB2 Expression in NALM6 Cells: 2.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>