LIPC [The Human Chemical-Genetic Interaction Map Project]

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======= LIPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIPC
  * **<color #00a2e8>Official Name</color>**: lipase C, hepatic type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3990|3990]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11150|P11150]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLAT|
|Lipase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intermediate-density lipoprotein particle remodeling|
|lipoprotein lipase activity|
|phosphatidylcholine catabolic process|
|triglyceride-rich lipoprotein particle clearance|
|chylomicron remnant clearance|
|very-low-density lipoprotein particle remodeling|
|low-density lipoprotein particle remodeling|
|triglyceride-rich lipoprotein particle remodeling|
|low-density lipoprotein particle binding|
|apolipoprotein binding|
|reverse cholesterol transport|
|phospholipase activity|
|high-density lipoprotein particle remodeling|
|regulation of lipoprotein lipase activity|
|glycerophospholipid catabolic process|
|high-density lipoprotein particle|
|triglyceride lipase activity|
|lipase activity|
|triglyceride catabolic process|
|protein-lipid complex remodeling|
|plasma lipoprotein particle remodeling|
|protein-containing complex remodeling|
|acylglycerol catabolic process|
|phospholipid catabolic process|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|neutral lipid catabolic process|
|plasma lipoprotein particle clearance|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|glycerolipid catabolic process|
|cholesterol transport|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|cholesterol metabolic process|
|fatty acid biosynthetic process|
|organophosphate catabolic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|organic hydroxy compound transport|
|heparin binding|
|monocarboxylic acid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|steroid metabolic process|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|endoplasmic reticulum lumen|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|lipid localization|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|lipid metabolic process|
|regulation of hydrolase activity|
|extracellular space|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.76|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.81|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18063
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIPC Expression in NALM6 Cells: 2.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>