LMAN1L [The Human Chemical-Genetic Interaction Map Project]

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======= LMAN1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LMAN1L
  * **<color #00a2e8>Official Name</color>**: lectin, mannose binding 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79748|79748]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAT1|Q9HAT1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LMAN1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LMAN1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609548|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin leg-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannose binding|
|COPII-coated ER to Golgi transport vesicle|
|endoplasmic reticulum organization|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|endoplasmic reticulum-Golgi intermediate compartment|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|collagen-containing extracellular matrix|
|Golgi vesicle transport|
|endomembrane system organization|
|Golgi membrane|
|endoplasmic reticulum membrane|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.83|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.05|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.91|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.74|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.73|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LMAN1L Expression in NALM6 Cells: -2.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>