LOX [The Human Chemical-Genetic Interaction Map Project]

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======= LOX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LOX
  * **<color #00a2e8>Official Name</color>**: lysyl oxidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4015|4015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28300|P28300]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LOX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LOX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153455|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:26838787}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lysyl oxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|descending aorta development|
|peptidyl-lysine oxidation|
|ascending aorta development|
|protein-lysine 6-oxidase activity|
|platelet-derived growth factor receptor-beta signaling pathway|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|elastic fiber assembly|
|protein oxidation|
|extracellular matrix assembly|
|muscle cell cellular homeostasis|
|regulation of bone development|
|regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of receptor binding|
|platelet-derived growth factor receptor signaling pathway|
|protein kinase B signaling|
|collagen fibril organization|
|bone mineralization|
|aorta development|
|regulation of megakaryocyte differentiation|
|copper ion binding|
|muscle fiber development|
|collagen trimer|
|artery development|
|cellular response to chemokine|
|response to chemokine|
|biomineralization|
|biomineral tissue development|
|DNA biosynthetic process|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|osteoblast differentiation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|striated muscle cell development|
|regulation of muscle organ development|
|muscle cell development|
|lung development|
|respiratory tube development|
|respiratory system development|
|striated muscle cell differentiation|
|cell chemotaxis|
|regulation of protein binding|
|connective tissue development|
|regulation of myeloid cell differentiation|
|extracellular matrix|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|muscle cell differentiation|
|ossification|
|regulation of cellular response to growth factor stimulus|
|peptidyl-lysine modification|
|response to steroid hormone|
|extracellular matrix organization|
|anatomical structure homeostasis|
|regulation of binding|
|extracellular structure organization|
|blood vessel morphogenesis|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|blood vessel development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|heart development|
|chemotaxis|
|taxis|
|response to wounding|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|tube development|
|response to lipid|
|circulatory system development|
|peptidyl-amino acid modification|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|cell migration|
|cellular response to cytokine stimulus|
|response to drug|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18261
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LOX Expression in NALM6 Cells: 0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>