LPAR3 [The Human Chemical-Genetic Interaction Map Project]

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======= LPAR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPAR3
  * **<color #00a2e8>Official Name</color>**: lysophosphatidic acid receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23566|23566]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBY5|Q9UBY5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPAR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPAR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605106|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysophosphatidic acid receptor activity|
|bleb assembly|
|positive regulation of collateral sprouting|
|regulation of collateral sprouting|
|G-protein alpha-subunit binding|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|positive regulation of axonogenesis|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|phospholipid binding|
|regulation of extent of cell growth|
|positive regulation of calcium ion transport|
|lipid binding|
|activation of MAPK activity|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|positive regulation of ion transport|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|regulation of cell growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|cell projection assembly|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPAR3 Expression in NALM6 Cells: 0.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>