LPIN1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LPIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPIN1
  * **<color #00a2e8>Official Name</color>**: lipin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23175|23175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14693|Q14693]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605518|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LNS2|
|Lipin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|triglyceride mobilization|
|mitotic nuclear envelope disassembly|
|phosphatidate phosphatase activity|
|phosphatidylethanolamine biosynthetic process|
|nuclear envelope disassembly|
|membrane disassembly|
|triglyceride biosynthetic process|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|phosphatidylethanolamine metabolic process|
|phosphatidylcholine biosynthetic process|
|nuclear envelope organization|
|animal organ regeneration|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|fatty acid catabolic process|
|positive regulation of cold-induced thermogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|monocarboxylic acid catabolic process|
|nucleus organization|
|regulation of cold-induced thermogenesis|
|regeneration|
|cellular response to insulin stimulus|
|mitochondrial outer membrane|
|nuclear envelope|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|response to insulin|
|nuclear membrane|
|phospholipid biosynthetic process|
|cellular response to peptide hormone stimulus|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|transcription coactivator activity|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|fatty acid metabolic process|
|cellular response to peptide|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|cellular component disassembly|
|endomembrane system organization|
|small molecule catabolic process|
|response to peptide|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|membrane organization|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to hormone|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|cell cycle process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|cell cycle|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.8|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5568
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPIN1 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>