LRP4 [The Human Chemical-Genetic Interaction Map Project]

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======= LRP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP4
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4038|4038]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75096|O75096]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VI56, ECO:0000269|PubMed:20381006, ECO:0000269|PubMed:21471202}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept b|
|SGL|
|EGF CA|
|cEGF|
|Ldl recept a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of presynaptic membrane organization|
|regulation of presynaptic membrane organization|
|positive regulation of skeletal muscle acetylcholine-gated channel clustering|
|synaptic growth at neuromuscular junction|
|positive regulation of postsynaptic membrane organization|
|regulation of skeletal muscle acetylcholine-gated channel clustering|
|positive regulation of neuromuscular junction development|
|positive regulation of receptor clustering|
|amyloid-beta clearance by cellular catabolic process|
|skeletal muscle acetylcholine-gated channel clustering|
|presynaptic membrane assembly|
|regulation of neuromuscular junction development|
|presynaptic membrane organization|
|regulation of receptor clustering|
|postsynaptic membrane assembly|
|regulation of postsynaptic membrane organization|
|apolipoprotein binding|
|postsynapse assembly|
|presynapse assembly|
|presynapse organization|
|amyloid-beta clearance|
|synaptic membrane|
|postsynaptic membrane organization|
|plasma membrane raft|
|proximal/distal pattern formation|
|protein heterotetramerization|
|membrane assembly|
|membrane biogenesis|
|neuromuscular junction development|
|receptor clustering|
|receptor tyrosine kinase binding|
|dendrite morphogenesis|
|scaffold protein binding|
|embryonic digit morphogenesis|
|negative regulation of axonogenesis|
|hair follicle development|
|skin epidermis development|
|negative regulation of ossification|
|hair cycle process|
|molting cycle process|
|neuromuscular junction|
|dorsal/ventral pattern formation|
|odontogenesis of dentin-containing tooth|
|localization within membrane|
|postsynapse organization|
|hair cycle|
|molting cycle|
|synapse assembly|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|dendrite development|
|protein heterooligomerization|
|odontogenesis|
|positive regulation of protein localization to membrane|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|limb morphogenesis|
|protein tetramerization|
|appendage morphogenesis|
|negative regulation of neuron projection development|
|negative regulation of canonical Wnt signaling pathway|
|limb development|
|appendage development|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|regulation of protein localization to membrane|
|regulation of ossification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of Wnt signaling pathway|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|kidney development|
|synapse organization|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|urogenital system development|
|positive regulation of cellular protein localization|
|regionalization|
|negative regulation of cell development|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|neuronal cell body|
|skin development|
|developmental growth|
|growth|
|epidermis development|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|protein complex oligomerization|
|regulation of cellular protein localization|
|endocytosis|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|cell surface|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10188
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP4 Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>