LRP5 [The Human Chemical-Genetic Interaction Map Project]

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======= LRP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP5
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4041|4041]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75197|O75197]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta- catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:27228167}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept b|
|Ldl recept a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor activity involved in Wnt signaling pathway|
|coreceptor activity involved in canonical Wnt signaling pathway|
|Norrin signaling pathway|
|Wnt-Frizzled-LRP5/6 complex|
|toxin transmembrane transporter activity|
|retinal blood vessel morphogenesis|
|bone marrow development|
|retina vasculature morphogenesis in camera-type eye|
|Wnt signalosome|
|retina vasculature development in camera-type eye|
|Wnt-activated receptor activity|
|osteoblast development|
|branching involved in mammary gland duct morphogenesis|
|positive regulation of mesenchymal cell proliferation|
|gastrulation with mouth forming second|
|mammary gland duct morphogenesis|
|glucose catabolic process|
|regulation of mesenchymal cell proliferation|
|adipose tissue development|
|Wnt-protein binding|
|toxin transport|
|mammary gland morphogenesis|
|negative regulation of osteoblast differentiation|
|bone remodeling|
|retina morphogenesis in camera-type eye|
|hexose catabolic process|
|positive regulation of mitotic nuclear division|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|mammary gland epithelium development|
|positive regulation of osteoblast differentiation|
|positive regulation of fat cell differentiation|
|monosaccharide catabolic process|
|positive regulation of nuclear division|
|negative regulation of ossification|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of ossification|
|canonical Wnt signaling pathway|
|gland morphogenesis|
|tissue remodeling|
|regulation of osteoblast differentiation|
|camera-type eye morphogenesis|
|bone morphogenesis|
|glucose metabolic process|
|carbohydrate catabolic process|
|regulation of fat cell differentiation|
|osteoblast differentiation|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein serine/threonine kinase activity|
|lipid homeostasis|
|retina development in camera-type eye|
|eye morphogenesis|
|positive regulation of mitotic cell cycle|
|hexose metabolic process|
|gastrulation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|regulation of mitotic nuclear division|
|regulation of insulin secretion|
|regulation of blood pressure|
|regulation of ossification|
|regulation of nuclear division|
|monosaccharide metabolic process|
|bone development|
|receptor complex|
|regulation of peptide hormone secretion|
|anterior/posterior pattern specification|
|connective tissue development|
|negative regulation of protein kinase activity|
|skeletal system morphogenesis|
|negative regulation of kinase activity|
|sensory organ morphogenesis|
|ossification|
|regulation of hormone secretion|
|negative regulation of transferase activity|
|positive regulation of cell cycle process|
|epithelial tube morphogenesis|
|camera-type eye development|
|regionalization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of cell cycle|
|blood circulation|
|circulatory system process|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|gland development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|small molecule catabolic process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|carbohydrate metabolic process|
|blood vessel development|
|skeletal system development|
|regulation of peptide secretion|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|regulation of hormone levels|
|sensory organ development|
|endocytosis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|immune system development|
|tube morphogenesis|
|import into cell|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|regulation of transferase activity|
|endoplasmic reticulum|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.45|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.76|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9814
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP5 Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>