LRPPRC [The Human Chemical-Genetic Interaction Map Project]

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======= LRPPRC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRPPRC
  * **<color #00a2e8>Official Name</color>**: leucine rich pentatricopeptide repeat containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10128|10128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42704|P42704]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRPPRC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRPPRC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607544|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial RNA catabolic process|
|regulation of mitochondrial RNA catabolic process|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|establishment of mitochondrion localization|
|nuclear outer membrane|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|condensed nuclear chromosome|
|beta-tubulin binding|
|mitochondrial nucleoid|
|nuclear inner membrane|
|mitochondrion localization|
|negative regulation of RNA catabolic process|
|organelle transport along microtubule|
|single-stranded DNA binding|
|mRNA transport|
|ribonucleoprotein complex|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|actin filament binding|
|RNA localization|
|microtubule binding|
|nucleobase-containing compound transport|
|negative regulation of cellular catabolic process|
|microtubule-based movement|
|ubiquitin protein ligase binding|
|negative regulation of catabolic process|
|microtubule|
|regulation of translation|
|establishment of organelle localization|
|cytoskeleton|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|organelle localization|
|microtubule-based process|
|perinuclear region of cytoplasm|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|mitochondrion|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.11|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.85|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.75|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.71|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.79|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.84|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.87|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.88|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.89|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.9|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.99|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.2|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.25|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.32|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.43|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.58|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.526|
|[[:human genes:m:mrps25|MRPS25]]|0.525|
|[[:human genes:c:coq2|COQ2]]|0.525|
|[[:human genes:p:pet117|PET117]]|0.511|
|[[:human genes:c:coa6|COA6]]|0.51|
|[[:human genes:f:fastkd5|FASTKD5]]|0.505|
|[[:human genes:n:ndufv1|NDUFV1]]|0.503|
|[[:human genes:n:nars2|NARS2]]|0.501|
|[[:human genes:m:mrps6|MRPS6]]|0.498|
|[[:human genes:c:coa3|COA3]]|0.497|
|[[:human genes:r:rpusd4|RPUSD4]]|0.492|
|[[:human genes:e:ears2|EARS2]]|0.489|
|[[:human genes:t:tars2|TARS2]]|0.486|
|[[:human genes:m:mrpl47|MRPL47]]|0.485|
|[[:human genes:m:mrps21|MRPS21]]|0.484|
|[[:human genes:m:mrps10|MRPS10]]|0.484|
|[[:human genes:m:mrps18a|MRPS18A]]|0.484|
|[[:human genes:m:mrpl4|MRPL4]]|0.483|
|[[:human genes:m:mrpl21|MRPL21]]|0.482|
|[[:human genes:v:vars2|VARS2]]|0.48|
|[[:human genes:f:ftsj2|FTSJ2]]|0.479|
|[[:human genes:m:mrps34|MRPS34]]|0.476|
|[[:human genes:y:yars2|YARS2]]|0.474|
|[[:human genes:m:mrps35|MRPS35]]|0.471|
|[[:human genes:m:mrp63|MRP63]]|0.471|
|[[:human genes:q:qrsl1|QRSL1]]|0.47|
|[[:human genes:s:sco2|SCO2]]|0.469|
|[[:human genes:m:mrps27|MRPS27]]|0.469|
|[[:human genes:c:cox15|COX15]]|0.468|
|[[:human genes:m:mrps24|MRPS24]]|0.464|
|[[:human genes:t:trub2|TRUB2]]|0.463|
|[[:human genes:c:cox7b|COX7B]]|0.463|
|[[:human genes:d:dap3|DAP3]]|0.461|
|[[:human genes:m:mrpl23|MRPL23]]|0.459|
|[[:human genes:r:rbfa|RBFA]]|0.459|
|[[:human genes:a:aars2|AARS2]]|0.458|
|[[:human genes:p:pet112|PET112]]|0.458|
|[[:human genes:m:mrps14|MRPS14]]|0.457|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.455|
|[[:human genes:c:cars2|CARS2]]|0.454|
|[[:human genes:m:mrpl53|MRPL53]]|0.454|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.454|
|[[:human genes:f:fastkd2|FASTKD2]]|0.453|
|[[:human genes:g:gfm1|GFM1]]|0.45|
|[[:human genes:m:mrps12|MRPS12]]|0.445|
|[[:human genes:m:mrpl55|MRPL55]]|0.444|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.444|
|[[:human genes:m:mrpl18|MRPL18]]|0.444|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.443|
|[[:human genes:f:fars2|FARS2]]|0.441|
|[[:human genes:m:mrps16|MRPS16]]|0.44|
|[[:human genes:h:higd2a|HIGD2A]]|0.44|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.44|
|[[:human genes:p:pnpt1|PNPT1]]|0.439|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.439|
|[[:human genes:p:ptcd3|PTCD3]]|0.438|
|[[:human genes:m:mrps26|MRPS26]]|0.434|
|[[:human genes:s:sars2|SARS2]]|0.432|
|[[:human genes:m:mrpl22|MRPL22]]|0.431|
|[[:human genes:m:mrpl1|MRPL1]]|0.429|
|[[:human genes:m:mrpl3|MRPL3]]|0.428|
|[[:human genes:m:mrps23|MRPS23]]|0.426|
|[[:human genes:n:ndufa3|NDUFA3]]|0.425|
|[[:human genes:m:mrpl43|MRPL43]]|0.425|
|[[:human genes:a:acad9|ACAD9]]|0.424|
|[[:human genes:l:lars2|LARS2]]|0.423|
|[[:human genes:w:wbscr16|WBSCR16]]|0.423|
|[[:human genes:t:tbrg4|TBRG4]]|0.423|
|[[:human genes:m:mettl17|METTL17]]|0.423|
|[[:human genes:r:rpusd3|RPUSD3]]|0.422|
|[[:human genes:m:mrpl45|MRPL45]]|0.421|
|[[:human genes:m:mtg1|MTG1]]|0.421|
|[[:human genes:c:cox6b1|COX6B1]]|0.419|
|[[:human genes:m:mtpap|MTPAP]]|0.419|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.418|
|[[:human genes:n:ndufs2|NDUFS2]]|0.417|
|[[:human genes:m:mrpl24|MRPL24]]|0.415|
|[[:human genes:n:ndufb11|NDUFB11]]|0.415|
|[[:human genes:m:mterfd2|MTERFD2]]|0.415|
|[[:human genes:c:cox16|COX16]]|0.414|
|[[:human genes:m:mars2|MARS2]]|0.414|
|[[:human genes:d:ddx28|DDX28]]|0.413|
|[[:human genes:s:slc31a1|SLC31A1]]|0.412|
|[[:human genes:c:c12orf65|C12orf65]]|0.412|
|[[:human genes:m:mrpl33|MRPL33]]|0.411|
|[[:human genes:a:alas1|ALAS1]]|0.407|
|[[:human genes:c:cox18|COX18]]|0.405|
|[[:human genes:c:cox6a1|COX6A1]]|0.404|
|[[:human genes:r:rars2|RARS2]]|0.404|
|[[:human genes:p:pars2|PARS2]]|0.404|
|[[:human genes:a:aifm1|AIFM1]]|0.403|
|[[:human genes:m:mrpl52|MRPL52]]|0.401|
|[[:human genes:w:wars2|WARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 163/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|9/28|
|blood|5/28|
|bone|5/26|
|breast|11/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|3/21|
|liver|5/20|
|lung|17/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 637
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRPPRC Expression in NALM6 Cells: 8.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>