LRR1 [The Human Chemical-Genetic Interaction Map Project]

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======= LRR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRR1
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=122769|122769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L50|Q96L50]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609193|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein modification|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.41|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.24|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.09|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.06|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.06|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.05|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.05|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.99|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.99|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.9|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.89|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.79|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.78|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.74|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.7|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.71|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.73|
|[[:results:exp302|35°C R06 exp302]]|1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.8|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.81|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.83|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.84|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.85|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.86|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.88|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.91|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.95|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.03|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.03|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.13|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.14|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.17|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.17|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.19|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.2|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.2|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.25|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.26|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.27|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.57|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.57|
|[[:human genes:c:ccna2|CCNA2]]|0.564|
|[[:human genes:p:psma6|PSMA6]]|0.555|
|[[:human genes:p:pwp2|PWP2]]|0.55|
|[[:human genes:p:psmd3|PSMD3]]|0.549|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.548|
|[[:human genes:c:chd4|CHD4]]|0.548|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.547|
|[[:human genes:d:ddtl|DDTL]]|0.541|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.54|
|[[:human genes:m:mt1e|MT1E]]|0.54|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.538|
|[[:human genes:a:akirin2|AKIRIN2]]|0.533|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.527|
|[[:human genes:n:nupl1|NUPL1]]|0.527|
|[[:human genes:c:cbwd3|CBWD3]]|0.527|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.526|
|[[:human genes:p:psmd11|PSMD11]]|0.525|
|[[:human genes:p:psmd1|PSMD1]]|0.524|
|[[:human genes:c:cbwd5|CBWD5]]|0.519|
|[[:human genes:b:bysl|BYSL]]|0.517|
|[[:human genes:p:psmb2|PSMB2]]|0.511|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.51|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.509|
|[[:human genes:v:vasn|VASN]]|0.509|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.509|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.509|
|[[:human genes:z:znf830|ZNF830]]|0.508|
|[[:human genes:r:rfc1|RFC1]]|0.506|
|[[:human genes:r:rps2|RPS2]]|0.498|
|[[:human genes:p:psma7|PSMA7]]|0.497|
|[[:human genes:p:psmd2|PSMD2]]|0.497|
|[[:human genes:u:upf1|UPF1]]|0.495|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.493|
|[[:human genes:n:nup160|NUP160]]|0.492|
|[[:human genes:p:psmd14|PSMD14]]|0.491|
|[[:human genes:m:med17|MED17]]|0.491|
|[[:human genes:r:rpl35|RPL35]]|0.49|
|[[:human genes:t:tfip11|TFIP11]]|0.49|
|[[:human genes:o:orc1|ORC1]]|0.489|
|[[:human genes:p:pan2|PAN2]]|0.489|
|[[:human genes:p:psmb4|PSMB4]]|0.486|
|[[:human genes:i:ik|IK]]|0.485|
|[[:human genes:h:hivep3|HIVEP3]]|0.485|
|[[:human genes:p:pan3|PAN3]]|0.484|
|[[:human genes:c:cbwd6|CBWD6]]|0.484|
|[[:human genes:t:tsg101|TSG101]]|0.483|
|[[:human genes:l:lad1|LAD1]]|0.478|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.477|
|[[:human genes:e:eif4a3|EIF4A3]]|0.476|
|[[:human genes:n:nup54|NUP54]]|0.476|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.475|
|[[:human genes:s:slc6a17|SLC6A17]]|0.475|
|[[:human genes:o:or10g3|OR10G3]]|0.474|
|[[:human genes:r:rpsa|RPSA]]|0.474|
|[[:human genes:k:kctd17|KCTD17]]|0.474|
|[[:human genes:n:nup205|NUP205]]|0.473|
|[[:human genes:t:tspy8|TSPY8]]|0.473|
|[[:human genes:x:xylt2|XYLT2]]|0.472|
|[[:human genes:c:cdc45|CDC45]]|0.471|
|[[:human genes:n:npipb5|NPIPB5]]|0.47|
|[[:human genes:c:c14orf93|C14orf93]]|0.469|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.466|
|[[:human genes:c:cope|COPE]]|0.466|
|[[:human genes:s:snip1|SNIP1]]|0.466|
|[[:human genes:r:rps7|RPS7]]|0.465|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.464|
|[[:human genes:s:supt5h|SUPT5H]]|0.464|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.463|
|[[:human genes:h:hap1|HAP1]]|0.463|
|[[:human genes:c:cactin|CACTIN]]|0.461|
|[[:human genes:r:rrp7a|RRP7A]]|0.461|
|[[:human genes:d:dtl|DTL]]|0.46|
|[[:human genes:c:chaf1a|CHAF1A]]|0.46|
|[[:human genes:e:exosc5|EXOSC5]]|0.459|
|[[:human genes:c:cdca3|CDCA3]]|0.457|
|[[:human genes:s:sf3a3|SF3A3]]|0.457|
|[[:human genes:c:copb1|COPB1]]|0.457|
|[[:human genes:r:rrn3|RRN3]]|0.456|
|[[:human genes:k:kpnb1|KPNB1]]|0.456|
|[[:human genes:a:aqr|AQR]]|0.455|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.454|
|[[:human genes:p:psmd7|PSMD7]]|0.453|
|[[:human genes:p:psmc3|PSMC3]]|0.452|
|[[:human genes:r:rps19|RPS19]]|0.451|
|[[:human genes:c:col2a1|COL2A1]]|0.451|
|[[:human genes:s:sf3a1|SF3A1]]|0.451|
|[[:human genes:h:hk1|HK1]]|0.449|
|[[:human genes:t:twistnb|TWISTNB]]|0.449|
|[[:human genes:r:rps3a|RPS3A]]|0.449|
|[[:human genes:c:ctage4|CTAGE4]]|0.449|
|[[:human genes:g:gid4|GID4]]|0.448|
|[[:human genes:p:pole|POLE]]|0.448|
|[[:human genes:c:ccdc94|CCDC94]]|0.448|
|[[:human genes:r:rps5|RPS5]]|0.448|
|[[:human genes:h:hinfp|HINFP]]|0.448|
|[[:human genes:a:ankle2|ANKLE2]]|0.448|
|[[:human genes:p:pcf11|PCF11]]|0.447|
|[[:human genes:t:tpx2|TPX2]]|0.447|
|[[:human genes:p:paf1|PAF1]]|0.446|
|[[:human genes:c:cdc73|CDC73]]|0.446|
|[[:human genes:r:rad21|RAD21]]|0.446|
|[[:human genes:l:loc643669|LOC643669]]|0.446|
|[[:human genes:d:dhx38|DHX38]]|0.446|
|[[:human genes:u:utp20|UTP20]]|0.444|
|[[:human genes:r:rps12|RPS12]]|0.444|
|[[:human genes:a:aamp|AAMP]]|0.443|
|[[:human genes:g:gar1|GAR1]]|0.443|
|[[:human genes:m:myo1h|MYO1H]]|0.442|
|[[:human genes:s:slc4a1|SLC4A1]]|0.441|
|[[:human genes:d:ddx56|DDX56]]|0.441|
|[[:human genes:e:exosc9|EXOSC9]]|0.44|
|[[:human genes:p:psmc1|PSMC1]]|0.438|
|[[:human genes:r:rad51|RAD51]]|0.437|
|[[:human genes:a:ankle1|ANKLE1]]|0.436|
|[[:human genes:r:rps14|RPS14]]|0.436|
|[[:human genes:f:fam160a1|FAM160A1]]|0.436|
|[[:human genes:r:rps9|RPS9]]|0.436|
|[[:human genes:n:nup133|NUP133]]|0.436|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.435|
|[[:human genes:s:slc38a7|SLC38A7]]|0.435|
|[[:human genes:e:elmod3|ELMOD3]]|0.435|
|[[:human genes:a:atp13a1|ATP13A1]]|0.434|
|[[:human genes:a:arcn1|ARCN1]]|0.434|
|[[:human genes:d:ddt|DDT]]|0.434|
|[[:human genes:n:narfl|NARFL]]|0.434|
|[[:human genes:w:wdr87|WDR87]]|0.434|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.433|
|[[:human genes:o:orc6|ORC6]]|0.433|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.433|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.432|
|[[:human genes:o:osbp|OSBP]]|0.432|
|[[:human genes:p:prpf8|PRPF8]]|0.431|
|[[:human genes:p:polr2f|POLR2F]]|0.43|
|[[:human genes:t:terf2|TERF2]]|0.429|
|[[:human genes:a:acsf2|ACSF2]]|0.429|
|[[:human genes:h:hmgcr|HMGCR]]|0.428|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.428|
|[[:human genes:o:or11h6|OR11H6]]|0.427|
|[[:human genes:c:cln6|CLN6]]|0.427|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.427|
|[[:human genes:z:znf106|ZNF106]]|0.426|
|[[:human genes:w:wdr75|WDR75]]|0.426|
|[[:human genes:m:med14|MED14]]|0.426|
|[[:human genes:p:pola1|POLA1]]|0.425|
|[[:human genes:n:npipb8|NPIPB8]]|0.424|
|[[:human genes:h:hcfc1|HCFC1]]|0.424|
|[[:human genes:z:zfand5|ZFAND5]]|0.424|
|[[:human genes:p:psmc2|PSMC2]]|0.423|
|[[:human genes:e:exosc8|EXOSC8]]|0.423|
|[[:human genes:g:golga6a|GOLGA6A]]|0.423|
|[[:human genes:p:plk1|PLK1]]|0.422|
|[[:human genes:p:pbxip1|PBXIP1]]|0.422|
|[[:human genes:c:c3|C3]]|0.422|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.422|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.422|
|[[:human genes:p:psmc5|PSMC5]]|0.421|
|[[:human genes:s:sec13|SEC13]]|0.42|
|[[:human genes:n:ndc1|NDC1]]|0.42|
|[[:human genes:f:fcn2|FCN2]]|0.42|
|[[:human genes:c:ckap5|CKAP5]]|0.42|
|[[:human genes:s:supt6h|SUPT6H]]|0.42|
|[[:human genes:p:pop1|POP1]]|0.419|
|[[:human genes:i:igfn1|IGFN1]]|0.419|
|[[:human genes:s:syt9|SYT9]]|0.418|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:c:ccdc116|CCDC116]]|0.417|
|[[:human genes:g:golga8o|GOLGA8O]]|0.417|
|[[:human genes:f:fam231c|FAM231C]]|0.416|
|[[:human genes:f:fam231a|FAM231A]]|0.416|
|[[:human genes:c:chmp2a|CHMP2A]]|0.415|
|[[:human genes:n:nop16|NOP16]]|0.415|
|[[:human genes:d:ddx21|DDX21]]|0.414|
|[[:human genes:s:ssh2|SSH2]]|0.414|
|[[:human genes:s:snrpa1|SNRPA1]]|0.414|
|[[:human genes:f:fam25b|FAM25B]]|0.413|
|[[:human genes:u:utp3|UTP3]]|0.413|
|[[:human genes:p:psma1|PSMA1]]|0.413|
|[[:human genes:r:rpl6|RPL6]]|0.412|
|[[:human genes:c:cep192|CEP192]]|0.412|
|[[:human genes:r:rps28|RPS28]]|0.412|
|[[:human genes:m:mfsd12|MFSD12]]|0.411|
|[[:human genes:a:adra1d|ADRA1D]]|0.411|
|[[:human genes:r:rffl|RFFL]]|0.411|
|[[:human genes:p:pigs|PIGS]]|0.41|
|[[:human genes:a:aaas|AAAS]]|0.41|
|[[:human genes:e:exosc3|EXOSC3]]|0.41|
|[[:human genes:m:madcam1|MADCAM1]]|0.41|
|[[:human genes:n:nol8|NOL8]]|0.41|
|[[:human genes:i:isy1|ISY1]]|0.409|
|[[:human genes:p:pde12|PDE12]]|0.409|
|[[:human genes:p:pdcd11|PDCD11]]|0.409|
|[[:human genes:a:aatf|AATF]]|0.409|
|[[:human genes:c:cgb2|CGB2]]|0.409|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.408|
|[[:human genes:n:noc4l|NOC4L]]|0.407|
|[[:human genes:r:rpl15|RPL15]]|0.407|
|[[:human genes:c:clptm1|CLPTM1]]|0.407|
|[[:human genes:d:dhfr|DHFR]]|0.406|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.406|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.406|
|[[:human genes:t:ticrr|TICRR]]|0.406|
|[[:human genes:t:tyms|TYMS]]|0.406|
|[[:human genes:p:polr2a|POLR2A]]|0.405|
|[[:human genes:k:krt78|KRT78]]|0.405|
|[[:human genes:g:golga8h|GOLGA8H]]|0.405|
|[[:human genes:p:ppfia4|PPFIA4]]|0.405|
|[[:human genes:s:sart1|SART1]]|0.405|
|[[:human genes:a:acbd4|ACBD4]]|0.404|
|[[:human genes:r:rnf113a|RNF113A]]|0.403|
|[[:human genes:c:c3orf17|C3orf17]]|0.403|
|[[:human genes:r:rpl14|RPL14]]|0.403|
|[[:human genes:r:rps3|RPS3]]|0.403|
|[[:human genes:g:gon4l|GON4L]]|0.402|
|[[:human genes:c:chst3|CHST3]]|0.402|
|[[:human genes:a:abt1|ABT1]]|0.401|
|[[:human genes:n:nup43|NUP43]]|0.401|
|[[:human genes:c:copz1|COPZ1]]|0.401|
|[[:human genes:r:rps11|RPS11]]|0.4|
|[[:human genes:x:xab2|XAB2]]|0.4|
|[[:human genes:m:myo18a|MYO18A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 397
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRR1 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>