LRRC16A [The Human Chemical-Genetic Interaction Map Project]

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======= LRRC16A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARMIL1
  * **<color #00a2e8>Official Name</color>**: capping protein regulator and myosin 1 linker 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55604|55604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VZK9|Q5VZK9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC16A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC16A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|barbed-end actin filament uncapping|
|actin filament uncapping|
|negative regulation of barbed-end actin filament capping|
|regulation of barbed-end actin filament capping|
|actin filament network formation|
|macropinocytosis|
|macropinosome|
|pinocytosis|
|urate metabolic process|
|positive regulation of actin filament depolymerization|
|positive regulation of protein depolymerization|
|ruffle organization|
|positive regulation of lamellipodium organization|
|filamentous actin|
|lamellipodium assembly|
|positive regulation of protein complex disassembly|
|positive regulation of substrate adhesion-dependent cell spreading|
|lamellipodium organization|
|regulation of lamellipodium organization|
|cell leading edge|
|positive regulation of stress fiber assembly|
|regulation of actin filament depolymerization|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of actin filament bundle assembly|
|regulation of stress fiber assembly|
|regulation of protein depolymerization|
|regulation of actomyosin structure organization|
|positive regulation of actin filament polymerization|
|regulation of actin filament bundle assembly|
|regulation of protein complex disassembly|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein polymerization|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|protein-containing complex binding|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|purine-containing compound metabolic process|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|nuclear speck|
|positive regulation of cell adhesion|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|wound healing|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of locomotion|
|endocytosis|
|actin filament-based process|
|response to wounding|
|positive regulation of organelle organization|
|import into cell|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|organic acid metabolic process|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|small molecule metabolic process|
|regulation of cell differentiation|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.74|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.7|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.27|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.16|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.94|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.9|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.84|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.75|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.74|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC16A Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>