LRRC63 [The Human Chemical-Genetic Interaction Map Project]

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======= LRRC63 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC63
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 63
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220416|220416]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05C16|Q05C16]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC63&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC63|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-3.09|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.01|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.96|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.94|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.72|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.71|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.74|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.74|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.75|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.79|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.81|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.81|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.82|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.97|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.98|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.98|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.03|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.05|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.08|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.19|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.21|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.21|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.24|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.27|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.28|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.28|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.51|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.67|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.82|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|3.01|
|[[:results:exp275|Citral 75μM R06 exp275]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14989
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC63 Expression in NALM6 Cells: -0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>