LRSAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= LRSAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRSAM1
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat and sterile alpha motif containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90678|90678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UWE0|Q6UWE0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRSAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRSAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610933|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|LRR 4|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent endocytosis|
|positive regulation of xenophagy|
|regulation of xenophagy|
|positive regulation of autophagosome assembly|
|positive regulation of vacuole organization|
|viral budding|
|regulation of autophagosome assembly|
|virion assembly|
|regulation of vacuole organization|
|negative regulation of endocytosis|
|protein autoubiquitination|
|positive regulation of macroautophagy|
|positive regulation of organelle assembly|
|positive regulation of autophagy|
|regulation of macroautophagy|
|viral life cycle|
|regulation of endocytosis|
|regulation of organelle assembly|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|autophagy|
|process utilizing autophagic mechanism|
|protein polyubiquitination|
|regulation of autophagy|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|positive regulation of defense response|
|negative regulation of transport|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|endocytosis|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|import into cell|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|regulation of response to stress|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRSAM1 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>