LSM10 [The Human Chemical-Genetic Interaction Map Project]

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======= LSM10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM10
  * **<color #00a2e8>Official Name</color>**: LSM10, U7 small nuclear RNA associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84967|84967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969L4|Q969L4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. {ECO:0000269|PubMed:16914750}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U7 snRNA binding|
|histone pre-mRNA DCP binding|
|U7 snRNP|
|histone mRNA metabolic process|
|termination of RNA polymerase II transcription|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cell cycle G1/S phase transition|
|Cajal body|
|DNA-templated transcription, termination|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of cell cycle phase transition|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|nuclear body|
|positive regulation of cell cycle process|
|positive regulation of cell cycle|
|RNA splicing|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|mRNA processing|
|transcription by RNA polymerase II|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of cell cycle process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.3|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.11|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.11|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.91|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.79|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.78|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.76|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.75|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.71|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.71|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.72|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.75|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.81|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.96|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fh|FH]]|0.602|
|[[:human genes:d:dhrsx|DHRSX]]|0.578|
|[[:human genes:r:rpia|RPIA]]|0.569|
|[[:human genes:s:slc25a26|SLC25A26]]|0.565|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.556|
|[[:human genes:p:pgm3|PGM3]]|0.554|
|[[:human genes:p:pmm2|PMM2]]|0.551|
|[[:human genes:t:thg1l|THG1L]]|0.547|
|[[:human genes:t:tmem242|TMEM242]]|0.546|
|[[:human genes:u:uhrf1|UHRF1]]|0.545|
|[[:human genes:s:srp14|SRP14]]|0.543|
|[[:human genes:t:ten1|TEN1]]|0.542|
|[[:human genes:t:trmt61a|TRMT61A]]|0.539|
|[[:human genes:g:gatc|GATC]]|0.537|
|[[:human genes:f:fastkd5|FASTKD5]]|0.536|
|[[:human genes:s:ssb|SSB]]|0.535|
|[[:human genes:b:bcs1l|BCS1L]]|0.535|
|[[:human genes:t:triap1|TRIAP1]]|0.533|
|[[:human genes:a:alg1|ALG1]]|0.533|
|[[:human genes:m:mrps34|MRPS34]]|0.531|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.53|
|[[:human genes:p:ppa2|PPA2]]|0.529|
|[[:human genes:s:srd5a3|SRD5A3]]|0.526|
|[[:human genes:d:dnlz|DNLZ]]|0.523|
|[[:human genes:m:mrps5|MRPS5]]|0.517|
|[[:human genes:p:ppcdc|PPCDC]]|0.516|
|[[:human genes:d:dars2|DARS2]]|0.514|
|[[:human genes:d:dohh|DOHH]]|0.51|
|[[:human genes:a:atp5j|ATP5J]]|0.509|
|[[:human genes:y:yars2|YARS2]]|0.508|
|[[:human genes:k:kctd5|KCTD5]]|0.507|
|[[:human genes:g:gemin8|GEMIN8]]|0.505|
|[[:human genes:s:selrc1|SELRC1]]|0.504|
|[[:human genes:p:ppp6c|PPP6C]]|0.504|
|[[:human genes:d:dpagt1|DPAGT1]]|0.502|
|[[:human genes:c:chchd4|CHCHD4]]|0.499|
|[[:human genes:a:atxn10|ATXN10]]|0.498|
|[[:human genes:u:uap1|UAP1]]|0.498|
|[[:human genes:d:dolk|DOLK]]|0.495|
|[[:human genes:t:trmt6|TRMT6]]|0.495|
|[[:human genes:m:mrps16|MRPS16]]|0.494|
|[[:human genes:r:rft1|RFT1]]|0.492|
|[[:human genes:p:pars2|PARS2]]|0.491|
|[[:human genes:p:ppp4c|PPP4C]]|0.491|
|[[:human genes:g:gmppb|GMPPB]]|0.491|
|[[:human genes:m:mrps6|MRPS6]]|0.49|
|[[:human genes:t:tpk1|TPK1]]|0.489|
|[[:human genes:m:mrpl23|MRPL23]]|0.489|
|[[:human genes:p:ppcs|PPCS]]|0.488|
|[[:human genes:g:gemin7|GEMIN7]]|0.487|
|[[:human genes:t:tars2|TARS2]]|0.487|
|[[:human genes:a:alg6|ALG6]]|0.485|
|[[:human genes:d:dap3|DAP3]]|0.483|
|[[:human genes:m:mrpl21|MRPL21]]|0.481|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.48|
|[[:human genes:r:rpp21|RPP21]]|0.479|
|[[:human genes:z:zcrb1|ZCRB1]]|0.479|
|[[:human genes:v:vezt|VEZT]]|0.478|
|[[:human genes:t:tbcb|TBCB]]|0.477|
|[[:human genes:r:rpusd4|RPUSD4]]|0.477|
|[[:human genes:t:tufm|TUFM]]|0.476|
|[[:human genes:a:atic|ATIC]]|0.475|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.475|
|[[:human genes:m:mrps14|MRPS14]]|0.473|
|[[:human genes:p:pmvk|PMVK]]|0.469|
|[[:human genes:r:rars2|RARS2]]|0.468|
|[[:human genes:t:txnrd1|TXNRD1]]|0.466|
|[[:human genes:n:nars2|NARS2]]|0.466|
|[[:human genes:z:zrsr2|ZRSR2]]|0.466|
|[[:human genes:r:rbfa|RBFA]]|0.466|
|[[:human genes:e:eif3f|EIF3F]]|0.462|
|[[:human genes:g:gfm2|GFM2]]|0.461|
|[[:human genes:c:c15orf41|C15orf41]]|0.461|
|[[:human genes:c:c12orf65|C12orf65]]|0.46|
|[[:human genes:a:alg13|ALG13]]|0.459|
|[[:human genes:s:sco2|SCO2]]|0.459|
|[[:human genes:r:rbmx2|RBMX2]]|0.459|
|[[:human genes:t:tsen54|TSEN54]]|0.457|
|[[:human genes:t:trmt5|TRMT5]]|0.457|
|[[:human genes:d:ddx39a|DDX39A]]|0.457|
|[[:human genes:p:polg|POLG]]|0.456|
|[[:human genes:r:rpe|RPE]]|0.456|
|[[:human genes:t:trmt10a|TRMT10A]]|0.456|
|[[:human genes:c:cox16|COX16]]|0.455|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.455|
|[[:human genes:a:atp5b|ATP5B]]|0.455|
|[[:human genes:g:gfpt1|GFPT1]]|0.453|
|[[:human genes:e:ears2|EARS2]]|0.453|
|[[:human genes:g:gfm1|GFM1]]|0.452|
|[[:human genes:r:rptor|RPTOR]]|0.451|
|[[:human genes:h:hccs|HCCS]]|0.447|
|[[:human genes:m:mrpl53|MRPL53]]|0.447|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.442|
|[[:human genes:h:hars|HARS]]|0.44|
|[[:human genes:t:tkt|TKT]]|0.44|
|[[:human genes:d:dr1|DR1]]|0.44|
|[[:human genes:t:tmem41b|TMEM41B]]|0.44|
|[[:human genes:c:cep57|CEP57]]|0.439|
|[[:human genes:s:slc25a19|SLC25A19]]|0.439|
|[[:human genes:w:wdr24|WDR24]]|0.438|
|[[:human genes:c:c17orf89|C17orf89]]|0.438|
|[[:human genes:a:alg5|ALG5]]|0.437|
|[[:human genes:u:utp23|UTP23]]|0.436|
|[[:human genes:c:cox17|COX17]]|0.432|
|[[:human genes:m:mrps11|MRPS11]]|0.432|
|[[:human genes:a:atp5d|ATP5D]]|0.432|
|[[:human genes:p:pdss1|PDSS1]]|0.432|
|[[:human genes:r:romo1|ROMO1]]|0.432|
|[[:human genes:e:elp2|ELP2]]|0.431|
|[[:human genes:m:mrps26|MRPS26]]|0.431|
|[[:human genes:k:kdsr|KDSR]]|0.43|
|[[:human genes:t:ttc4|TTC4]]|0.427|
|[[:human genes:t:taf1a|TAF1A]]|0.427|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.427|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.427|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.426|
|[[:human genes:p:pus3|PUS3]]|0.425|
|[[:human genes:m:mrps2|MRPS2]]|0.425|
|[[:human genes:c:cbx3|CBX3]]|0.424|
|[[:human genes:n:nbn|NBN]]|0.423|
|[[:human genes:a:adsl|ADSL]]|0.422|
|[[:human genes:t:tubd1|TUBD1]]|0.421|
|[[:human genes:v:vars2|VARS2]]|0.421|
|[[:human genes:m:mrps18a|MRPS18A]]|0.421|
|[[:human genes:c:c10orf2|C10orf2]]|0.42|
|[[:human genes:c:cycs|CYCS]]|0.42|
|[[:human genes:u:urm1|URM1]]|0.42|
|[[:human genes:e:elp3|ELP3]]|0.419|
|[[:human genes:b:bap1|BAP1]]|0.419|
|[[:human genes:e:eef1e1|EEF1E1]]|0.418|
|[[:human genes:p:pelo|PELO]]|0.418|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.418|
|[[:human genes:q:qrsl1|QRSL1]]|0.418|
|[[:human genes:t:timm22|TIMM22]]|0.417|
|[[:human genes:r:rabggtb|RABGGTB]]|0.416|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.415|
|[[:human genes:p:pik3r4|PIK3R4]]|0.414|
|[[:human genes:c:ctc1|CTC1]]|0.414|
|[[:human genes:h:hars2|HARS2]]|0.414|
|[[:human genes:o:opa1|OPA1]]|0.414|
|[[:human genes:p:pggt1b|PGGT1B]]|0.414|
|[[:human genes:m:med16|MED16]]|0.413|
|[[:human genes:n:n6amt1|N6AMT1]]|0.412|
|[[:human genes:c:c1d|C1D]]|0.412|
|[[:human genes:l:lsm11|LSM11]]|0.412|
|[[:human genes:c:cbfb|CBFB]]|0.412|
|[[:human genes:m:med25|MED25]]|0.411|
|[[:human genes:n:nae1|NAE1]]|0.41|
|[[:human genes:r:rtcb|RTCB]]|0.41|
|[[:human genes:w:wdr92|WDR92]]|0.409|
|[[:human genes:a:atp5a1|ATP5A1]]|0.409|
|[[:human genes:g:gemin6|GEMIN6]]|0.409|
|[[:human genes:t:taz|TAZ]]|0.408|
|[[:human genes:m:mrps33|MRPS33]]|0.408|
|[[:human genes:w:wdr59|WDR59]]|0.407|
|[[:human genes:p:ppa1|PPA1]]|0.407|
|[[:human genes:e:exoc4|EXOC4]]|0.406|
|[[:human genes:s:sdha|SDHA]]|0.406|
|[[:human genes:e:elac2|ELAC2]]|0.405|
|[[:human genes:m:mars2|MARS2]]|0.405|
|[[:human genes:c:crls1|CRLS1]]|0.405|
|[[:human genes:r:rnmt|RNMT]]|0.404|
|[[:human genes:p:ptar1|PTAR1]]|0.403|
|[[:human genes:p:paxip1|PAXIP1]]|0.402|
|[[:human genes:z:znhit1|ZNHIT1]]|0.401|
|[[:human genes:c:cox5a|COX5A]]|0.401|
|[[:human genes:p:ptdss1|PTDSS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM10 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>