LSM14A [The Human Chemical-Genetic Interaction Map Project]

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======= LSM14A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM14A
  * **<color #00a2e8>Official Name</color>**: LSM14A mRNA processing body assembly factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26065|26065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8ND56|Q8ND56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM14A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM14A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610677|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FFD TFG|
|DFDF|
|LSM14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RIG-I signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway in response to virus|
|cytoplasmic mRNA processing body assembly|
|positive regulation of type I interferon-mediated signaling pathway|
|multi-organism cellular process|
|cellular response to virus|
|regulation of type I interferon-mediated signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|single-stranded RNA binding|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of response to cytokine stimulus|
|cytoplasmic stress granule|
|cytoplasmic ribonucleoprotein granule|
|double-stranded RNA binding|
|P-body|
|double-stranded DNA binding|
|pattern recognition receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|intracellular receptor signaling pathway|
|regulation of response to cytokine stimulus|
|defense response to virus|
|ribonucleoprotein complex assembly|
|innate immune response-activating signal transduction|
|ribonucleoprotein complex subunit organization|
|activation of innate immune response|
|response to virus|
|positive regulation of innate immune response|
|regulation of translation|
|positive regulation of response to biotic stimulus|
|regulation of cellular amide metabolic process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of cytokine production|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|defense response to other organism|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.96|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.94|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.84|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.71|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.81|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.85|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.91|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.37|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.75|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM14A Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>