LTF [The Human Chemical-Genetic Interaction Map Project]

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======= LTF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LTF
  * **<color #00a2e8>Official Name</color>**: lactotransferrin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4057|4057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02788|P02788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LTF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LTF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transferrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of bone mineralization involved in bone maturation|
|siderophore-dependent iron import into cell|
|negative regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|negative regulation of single-species biofilm formation|
|negative regulation of single-species biofilm formation in or on host organism|
|regulation of single-species biofilm formation in or on host organism|
|regulation of single-species biofilm formation|
|regulation of tumor necrosis factor (ligand) superfamily member 11 production|
|phagocytic vesicle lumen|
|other organism cell membrane|
|positive regulation of chondrocyte proliferation|
|iron import into cell|
|antifungal humoral response|
|regulation of bone mineralization involved in bone maturation|
|negative regulation of osteoclast development|
|positive regulation of bone development|
|positive regulation of toll-like receptor 4 signaling pathway|
|membrane disruption in other organism|
|positive regulation of osteoblast proliferation|
|negative regulation of bone development|
|regulation of osteoclast development|
|negative regulation by host of viral process|
|iron coordination entity transport|
|specific granule|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|innate immune response in mucosa|
|negative regulation of ATPase activity|
|regulation of toll-like receptor 4 signaling pathway|
|regulation of osteoblast proliferation|
|positive regulation of toll-like receptor signaling pathway|
|regulation of bone development|
|regulation of lipopolysaccharide-mediated signaling pathway|
|negative regulation of osteoclast differentiation|
|modulation by host of viral process|
|mucosal immune response|
|protein serine/threonine kinase activator activity|
|organ or tissue specific immune response|
|cysteine-type endopeptidase inhibitor activity|
|lipopolysaccharide binding|
|defense response to fungus|
|antibacterial humoral response|
|positive regulation of bone mineralization|
|negative regulation of myeloid leukocyte differentiation|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|response to fungus|
|killing of cells of other organism|
|disruption of cells of other organism|
|tertiary granule lumen|
|negative regulation of viral genome replication|
|positive regulation of osteoblast differentiation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|specific granule lumen|
|cellular iron ion homeostasis|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|regulation of osteoclast differentiation|
|regulation of toll-like receptor signaling pathway|
|iron ion transport|
|modification by host of symbiont morphology or physiology|
|retina homeostasis|
|regulation of bone mineralization|
|negative regulation of myeloid cell differentiation|
|interaction with symbiont|
|iron ion homeostasis|
|regulation of ATPase activity|
|negative regulation of viral life cycle|
|defense response to Gram-negative bacterium|
|positive regulation of ossification|
|secretory granule|
|cell killing|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of biomineralization|
|negative regulation of response to biotic stimulus|
|regulation of biomineral tissue development|
|regulation of viral genome replication|
|negative regulation of viral process|
|negative regulation of leukocyte differentiation|
|cellular transition metal ion homeostasis|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|regulation of myeloid leukocyte differentiation|
|transition metal ion transport|
|transition metal ion homeostasis|
|iron ion binding|
|negative regulation of hemopoiesis|
|regulation of viral life cycle|
|regulation of tumor necrosis factor production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|modification of morphology or physiology of other organism|
|serine-type endopeptidase activity|
|heparin binding|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of ossification|
|tissue homeostasis|
|bone development|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of myeloid cell differentiation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|ossification|
|positive regulation of DNA-binding transcription factor activity|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|multicellular organismal homeostasis|
|defense response to bacterium|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|humoral immune response|
|negative regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|skeletal system development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|protein-containing complex|
|positive regulation of response to external stimulus|
|cell surface|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|import into cell|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|cation transport|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LTF Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>