LY96 [The Human Chemical-Genetic Interaction Map Project]

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======= LY96 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LY96
  * **<color #00a2e8>Official Name</color>**: lymphocyte antigen 96
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23643|23643]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6Y9|Q9Y6Y9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LY96&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LY96|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11160242, ECO:0000269|PubMed:11593030, ECO:0000269|PubMed:17569869, ECO:0000269|PubMed:17803912}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1 DerP2 DerF2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of lipopolysaccharide|
|lipopolysaccharide receptor complex|
|lipopolysaccharide receptor activity|
|Toll-like receptor 4 binding|
|negative regulation of MyD88-independent toll-like receptor signaling pathway|
|regulation of MyD88-independent toll-like receptor signaling pathway|
|positive regulation of lipopolysaccharide-mediated signaling pathway|
|detection of molecule of bacterial origin|
|toll-like receptor 4 signaling pathway|
|detection of external biotic stimulus|
|detection of biotic stimulus|
|necroptotic process|
|regulation of lipopolysaccharide-mediated signaling pathway|
|programmed necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|necrotic cell death|
|MyD88-independent toll-like receptor signaling pathway|
|MyD88-dependent toll-like receptor signaling pathway|
|lipopolysaccharide-mediated signaling pathway|
|coreceptor activity|
|lipopolysaccharide binding|
|intrinsic component of plasma membrane|
|negative regulation of toll-like receptor signaling pathway|
|cellular defense response|
|regulation of toll-like receptor signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|toll-like receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|endosome membrane|
|cellular response to biotic stimulus|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|apoptotic signaling pathway|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|detection of chemical stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|detection of stimulus|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|response to lipid|
|positive regulation of immune response|
|apoptotic process|
|defense response to other organism|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.34|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.85|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.83|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.71|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.75|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.86|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.88|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LY96 Expression in NALM6 Cells: 0.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>