LYPD1 [The Human Chemical-Genetic Interaction Map Project]

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======= LYPD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LYPD1
  * **<color #00a2e8>Official Name</color>**: LY6/PLAUR domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116372|116372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2G4|Q8N2G4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LYPD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LYPD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha- 4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. {ECO:0000250|UniProtKB:Q8BLC3}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetylcholine receptor inhibitor activity|
|acetylcholine receptor binding|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|synaptic transmission, cholinergic|
|behavioral fear response|
|acetylcholine receptor signaling pathway|
|negative regulation of protein localization to membrane|
|behavioral defense response|
|response to acetylcholine|
|cellular response to acetylcholine|
|fear response|
|postsynaptic signal transduction|
|response to nicotine|
|negative regulation of signaling receptor activity|
|multicellular organismal response to stress|
|signal transduction involved in cellular response to ammonium ion|
|regulation of protein localization to plasma membrane|
|anchored component of membrane|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|cellular response to ammonium ion|
|regulation of signaling receptor activity|
|response to ammonium ion|
|regulation of protein localization to membrane|
|cellular response to drug|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|regulation of cellular protein localization|
|behavior|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|response to hormone|
|regulation of cellular localization|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|defense response|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LYPD1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>