M6PR [The Human Chemical-Genetic Interaction Map Project]

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======= M6PR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: M6PR
  * **<color #00a2e8>Official Name</color>**: mannose-6-phosphate receptor, cation dependent
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4074|4074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20645|P20645]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=M6PR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20M6PR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Man-6-P recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retromer complex binding|
|secretion of lysosomal enzymes|
|protein targeting to lysosome|
|mannose binding|
|protein targeting to vacuole|
|protein localization to lysosome|
|establishment of protein localization to vacuole|
|clathrin-coated vesicle membrane|
|endosome to lysosome transport|
|protein localization to vacuole|
|transport vesicle|
|trans-Golgi network membrane|
|lysosomal transport|
|late endosome|
|transmembrane signaling receptor activity|
|vacuolar transport|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|trans-Golgi network|
|peptide secretion|
|receptor-mediated endocytosis|
|protein domain specific binding|
|endosome|
|lysosomal membrane|
|protein targeting|
|establishment of protein localization to organelle|
|endocytosis|
|import into cell|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|membrane organization|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|secretion|
|integral component of plasma membrane|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.82|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.88|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2815
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='M6PR Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>