MAGT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MAGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAGT1
  * **<color #00a2e8>Official Name</color>**: magnesium transporter 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84061|84061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0U3|Q9H0U3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300715|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. {ECO:0000269|PubMed:25135935, ECO:0000269|PubMed:26864433, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OST3 OST6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|magnesium ion transmembrane transporter activity|
|magnesium ion transmembrane transport|
|magnesium ion transport|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|azurophil granule membrane|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|peptidyl-amino acid modification|
|leukocyte activation|
|ion transmembrane transport|
|secretion by cell|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.18|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.8|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.75|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.87|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.5|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.5|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.71|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.91|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.79|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|4.29|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|4.87|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|5.96|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|6.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:stt3b|STT3B]]|0.651|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12739
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAGT1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>