MAP3K7 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP3K7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP3K7
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase kinase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6885|6885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43318|O43318]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP3K7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP3K7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IkappaB kinase complex|
|anoikis|
|I-kappaB phosphorylation|
|Ada2/Gcn5/Ada3 transcription activator complex|
|activation of NF-kappaB-inducing kinase activity|
|positive regulation of T cell cytokine production|
|MAP kinase kinase kinase activity|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|positive regulation of interleukin-2 production|
|regulation of T cell cytokine production|
|MyD88-dependent toll-like receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|histone H3 acetylation|
|positive regulation of T cell mediated immunity|
|activation of MAPKK activity|
|regulation of interleukin-2 production|
|positive regulation of cytokine production involved in immune response|
|receptor tyrosine kinase binding|
|scaffold protein binding|
|positive regulation of macroautophagy|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of T cell mediated immunity|
|positive regulation of JUN kinase activity|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|JNK cascade|
|regulation of cytokine production involved in immune response|
|regulation of JUN kinase activity|
|interleukin-1-mediated signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|toll-like receptor signaling pathway|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|stress-activated MAPK cascade|
|regulation of NIK/NF-kappaB signaling|
|stimulatory C-type lectin receptor signaling pathway|
|histone acetylation|
|innate immune response activating cell surface receptor signaling pathway|
|internal peptidyl-lysine acetylation|
|positive regulation of autophagy|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte mediated immunity|
|non-canonical Wnt signaling pathway|
|positive regulation of JNK cascade|
|regulation of production of molecular mediator of immune response|
|stress-activated protein kinase signaling cascade|
|protein acetylation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|activation of MAPK activity|
|cellular response to transforming growth factor beta stimulus|
|regulation of adaptive immune response|
|response to transforming growth factor beta|
|intracellular receptor signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of macroautophagy|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|protein acylation|
|response to interleukin-1|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of leukocyte mediated immunity|
|endosome membrane|
|magnesium ion binding|
|positive regulation of immune effector process|
|innate immune response-activating signal transduction|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|Fc receptor signaling pathway|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|activation of protein kinase activity|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|histone modification|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|covalent chromatin modification|
|signal transduction by protein phosphorylation|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|cellular response to growth factor stimulus|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|chromatin organization|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|apoptotic process|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|chromosome organization|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-3.04|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.6|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.24|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.22|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.16|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.15|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.98|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.85|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.78|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.76|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP3K7 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>