MAPK10 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPK10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK10
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5602|5602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53779|P53779]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22441692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|JUN kinase activity|
|JUN phosphorylation|
|response to water deprivation|
|cellular hyperosmotic response|
|MAP kinase activity|
|response to water|
|MAP kinase kinase activity|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|establishment of protein localization to postsynaptic membrane|
|hyperosmotic response|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|cellular response to osmotic stress|
|receptor localization to synapse|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|protein localization to synapse|
|response to osmotic stress|
|JNK cascade|
|vesicle-mediated transport to the plasma membrane|
|stress-activated MAPK cascade|
|regulation of circadian rhythm|
|vesicle-mediated transport in synapse|
|perikaryon|
|stress-activated protein kinase signaling cascade|
|activation of MAPK activity|
|Fc-epsilon receptor signaling pathway|
|protein localization to cell periphery|
|Fc receptor signaling pathway|
|protein-containing complex localization|
|positive regulation of MAP kinase activity|
|establishment of protein localization to membrane|
|rhythmic process|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|neuron projection|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|glutamatergic synapse|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of transferase activity|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK10 Expression in NALM6 Cells: -0.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>