MAPK7 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPK7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK7
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5598|5598]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13164|Q13164]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cyclic-nucleotide phosphodiesterase activity|
|cellular response to laminar fluid shear stress|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|negative regulation of calcineurin-NFAT signaling cascade|
|MAP kinase activity|
|negative regulation of calcineurin-mediated signaling|
|response to laminar fluid shear stress|
|cellular response to fluid shear stress|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|mitogen-activated protein kinase binding|
|regulation of heterotypic cell-cell adhesion|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of endothelial cell apoptotic process|
|negative regulation of calcium-mediated signaling|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|response to fluid shear stress|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of gastrulation|
|negative regulation of epithelial cell apoptotic process|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of response to oxidative stress|
|regulation of endothelial cell apoptotic process|
|regulation of oxidative stress-induced cell death|
|negative regulation of response to cytokine stimulus|
|cellular response to hydrogen peroxide|
|regulation of cellular response to oxidative stress|
|regulation of epithelial cell apoptotic process|
|regulation of response to oxidative stress|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of calcium-mediated signaling|
|PML body|
|negative regulation of extrinsic apoptotic signaling pathway|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|regulation of embryonic development|
|cellular response to reactive oxygen species|
|negative regulation of inflammatory response|
|cAMP-mediated signaling|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|regulation of intrinsic apoptotic signaling pathway|
|response to transforming growth factor beta|
|cyclic-nucleotide-mediated signaling|
|peptidyl-serine phosphorylation|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|response to reactive oxygen species|
|peptidyl-serine modification|
|negative regulation of defense response|
|cellular response to toxic substance|
|negative regulation of apoptotic signaling pathway|
|cellular response to oxidative stress|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell adhesion|
|regulation of angiogenesis|
|response to antibiotic|
|regulation of vasculature development|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|MAPK cascade|
|axonogenesis|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of hydrolase activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|cell part morphogenesis|
|response to growth factor|
|response to inorganic substance|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|regulation of cell adhesion|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of defense response|
|negative regulation of catalytic activity|
|neuron development|
|cellular component morphogenesis|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|negative regulation of cell death|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.87|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.77|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.81|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.91|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.08|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK7 Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>