MAPRE2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPRE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPRE2
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein RP/EB family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10982|10982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15555|Q15555]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPRE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPRE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605789|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|EB1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ARF protein signal transduction|
|protein localization to microtubule end|
|protein localization to microtubule plus-end|
|protein localization to microtubule|
|positive regulation of keratinocyte migration|
|regulation of keratinocyte migration|
|microtubule plus-end binding|
|regulation of ARF protein signal transduction|
|microtubule plus-end|
|spindle midzone|
|positive regulation of adherens junction organization|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|cytoplasmic microtubule|
|positive regulation of Ras protein signal transduction|
|regulation of adherens junction organization|
|positive regulation of small GTPase mediated signal transduction|
|regulation of microtubule polymerization or depolymerization|
|spindle assembly|
|positive regulation of epithelial cell migration|
|microtubule cytoskeleton|
|spindle organization|
|microtubule organizing center|
|regulation of microtubule cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|microtubule binding|
|regulation of Ras protein signal transduction|
|microtubule|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|focal adhesion|
|protein kinase binding|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|cell division|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|microtubule-based process|
|protein localization to organelle|
|organelle assembly|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPRE2 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>