MAPT [The Human Chemical-Genetic Interaction Map Project]

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======= MAPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPT
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein tau
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4137|4137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10636|P10636]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of diacylglycerol kinase activity|
|regulation of diacylglycerol kinase activity|
|neurofibrillary tangle assembly|
|histone-dependent DNA binding|
|tubulin complex|
|microtubule lateral binding|
|negative regulation of mitochondrial fission|
|neurofibrillary tangle|
|negative regulation of tubulin deacetylation|
|phosphatidylinositol bisphosphate binding|
|lipoprotein particle binding|
|inclusion body assembly|
|main axon|
|plus-end-directed organelle transport along microtubule|
|negative regulation of establishment of protein localization to mitochondrion|
|intracellular distribution of mitochondria|
|amyloid fibril formation|
|AT DNA binding|
|regulation of tubulin deacetylation|
|positive regulation of protein localization to synapse|
|glial cell projection|
|cellular response to brain-derived neurotrophic factor stimulus|
|dynactin binding|
|somatodendritic compartment|
|negative regulation of mitochondrial membrane potential|
|axonal transport of mitochondrion|
|negative regulation of membrane potential|
|nuclear periphery|
|regulation of long-term synaptic depression|
|axolemma|
|stress granule assembly|
|apolipoprotein binding|
|mitochondrion distribution|
|positive regulation of superoxide anion generation|
|astrocyte activation|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|regulation of superoxide anion generation|
|regulation of mitochondrial fission|
|response to lead ion|
|establishment of mitochondrion localization|
|regulation of protein localization to synapse|
|positive regulation of microtubule polymerization|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|microtubule polymerization|
|protein phosphatase 2A binding|
|regulation of superoxide metabolic process|
|receptor ligand activity|
|positive regulation of microtubule polymerization or depolymerization|
|astrocyte development|
|glial cell activation|
|neuroinflammatory response|
|Hsp90 protein binding|
|regulation of protein deacetylation|
|positive regulation of axon extension|
|mitochondrion localization|
|cellular response to nerve growth factor stimulus|
|macrophage activation|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|response to nerve growth factor|
|cytoplasmic microtubule organization|
|negative regulation of mitochondrion organization|
|astrocyte differentiation|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|cytoplasmic ribonucleoprotein granule|
|regulation of mitochondrial membrane potential|
|cellular response to heat|
|regulation of establishment of protein localization to mitochondrion|
|cell body|
|organelle transport along microtubule|
|regulation of cellular response to heat|
|protein binding, bridging|
|central nervous system neuron development|
|regulation of microtubule polymerization or depolymerization|
|cell|
|positive regulation of axonogenesis|
|protein polymerization|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|phosphatidylinositol binding|
|positive regulation of neuron death|
|positive regulation of reactive oxygen species metabolic process|
|regulation of calcium-mediated signaling|
|regulation of axon extension|
|chaperone binding|
|double-stranded DNA binding|
|glial cell development|
|single-stranded DNA binding|
|response to heat|
|regulation of extent of cell growth|
|negative regulation of cellular protein localization|
|memory|
|internal protein amino acid acetylation|
|positive regulation of protein polymerization|
|growth cone|
|SH3 domain binding|
|cellular response to reactive oxygen species|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein acetylation|
|dendritic spine|
|positive regulation of cysteine-type endopeptidase activity|
|microtubule cytoskeleton|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|positive regulation of cell growth|
|glial cell differentiation|
|positive regulation of developmental growth|
|positive regulation of endopeptidase activity|
|cytoskeleton-dependent intracellular transport|
|response to temperature stimulus|
|central nervous system neuron differentiation|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|regulation of cell size|
|microtubule-based transport|
|regulation of axonogenesis|
|negative regulation of establishment of protein localization|
|protein acylation|
|regulation of synaptic plasticity|
|regulation of microtubule cytoskeleton organization|
|positive regulation of peptidase activity|
|response to reactive oxygen species|
|positive regulation of supramolecular fiber organization|
|gliogenesis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to DNA damage stimulus|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|rRNA metabolic process|
|regulation of protein polymerization|
|membrane raft|
|ribonucleoprotein complex assembly|
|microtubule binding|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|negative regulation of kinase activity|
|positive regulation of protein complex assembly|
|learning or memory|
|positive regulation of growth|
|actin binding|
|synapse organization|
|microtubule-based movement|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|microtubule|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regulation of autophagy|
|enzyme binding|
|regulation of chromosome organization|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|response to metal ion|
|neuronal cell body|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|response to oxidative stress|
|nuclear speck|
|axon development|
|regulation of cell growth|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|dendrite|
|regulation of membrane potential|
|mitochondrion organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|positive regulation of neurogenesis|
|ncRNA metabolic process|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|cellular response to growth factor stimulus|
|regulation of anatomical structure size|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|response to inorganic substance|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|positive regulation of kinase activity|
|organelle localization|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of establishment of protein localization|
|organelle assembly|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|neuron development|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of catabolic process|
|neuron differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|RNA binding|
|positive regulation of catalytic activity|
|DNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPT Expression in NALM6 Cells: 2.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>