MARCH6 [The Human Chemical-Genetic Interaction Map Project]

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======= MARCH6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARCHF6
  * **<color #00a2e8>Official Name</color>**: membrane associated ring-CH-type finger 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10299|10299]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60337|O60337]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARCH6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARCH6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RINGv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER ubiquitin ligase complex|
|endoplasmic reticulum mannose trimming|
|ubiquitin-specific protease binding|
|protein alpha-1,2-demannosylation|
|protein demannosylation|
|endoplasmic reticulum quality control compartment|
|protein deglycosylation|
|ubiquitin conjugating enzyme binding|
|protein K48-linked ubiquitination|
|ubiquitin-dependent ERAD pathway|
|ERAD pathway|
|integral component of endoplasmic reticulum membrane|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|response to endoplasmic reticulum stress|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|enzyme binding|
|proteasomal protein catabolic process|
|glycoprotein metabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|zinc ion binding|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.97|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.3|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.8|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.72|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.73|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARCH6 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>