MARVELD1 [The Human Chemical-Genetic Interaction Map Project]

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======= MARVELD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARVELD1
  * **<color #00a2e8>Official Name</color>**: MARVEL domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83742|83742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSK0|Q9BSK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARVELD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARVELD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MARVEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of myelin sheath|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|cytoskeleton|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.92|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.3|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-2.08|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.97|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.85|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.85|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.84|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.83|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.82|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.8|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.8|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.84|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.84|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.92|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.95|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.98|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.01|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.13|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.2|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.24|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.3|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.33|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.41|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.58|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12673
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARVELD1 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>