MAS1 [The Human Chemical-Genetic Interaction Map Project]

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======= MAS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAS1
  * **<color #00a2e8>Official Name</color>**: MAS1 proto-oncogene, G protein-coupled receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4142|4142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04201|P04201]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|angiotensin receptor activity|
|angiotensin type II receptor activity|
|angiotensin-activated signaling pathway|
|positive regulation of inositol phosphate biosynthetic process|
|protein kinase C signaling|
|regulation of inositol phosphate biosynthetic process|
|activation of NF-kappaB-inducing kinase activity|
|cellular response to angiotensin|
|positive regulation of alcohol biosynthetic process|
|response to angiotensin|
|response to gonadotropin|
|positive regulation of DNA replication|
|peptide binding|
|positive regulation of cellular carbohydrate metabolic process|
|response to activity|
|regulation of alcohol biosynthetic process|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of carbohydrate metabolic process|
|NIK/NF-kappaB signaling|
|hippocampus development|
|regulation of carbohydrate biosynthetic process|
|regulation of DNA replication|
|limbic system development|
|regulation of NIK/NF-kappaB signaling|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|male sex differentiation|
|pallium development|
|regulation of carbohydrate metabolic process|
|gonad development|
|development of primary sexual characteristics|
|telencephalon development|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of inflammatory response|
|forebrain development|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|negative regulation of phosphorylation|
|response to peptide|
|positive regulation of protein kinase activity|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|gamete generation|
|G protein-coupled receptor activity|
|brain development|
|regulation of defense response|
|head development|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|central nervous system development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.03|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17657
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAS1 Expression in NALM6 Cells: 3.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>