MAU2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAU2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAU2
  * **<color #00a2e8>Official Name</color>**: MAU2 sister chromatid cohesion factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23383|23383]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X3|Q9Y6X3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAU2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAU2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347). {ECO:0000269|PubMed:16682347, ECO:0000269|PubMed:16802858, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cohesin load|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Scc2-Scc4 cohesin loading complex|
|SMC loading complex|
|cohesin loading|
|maintenance of mitotic sister chromatid cohesion|
|maintenance of sister chromatid cohesion|
|establishment of sister chromatid cohesion|
|mitotic sister chromatid cohesion|
|protein localization to chromatin|
|sister chromatid cohesion|
|positive regulation of DNA binding|
|protein localization to chromosome|
|double-stranded DNA binding|
|protein N-terminus binding|
|mitotic sister chromatid segregation|
|chromatin|
|regulation of DNA binding|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of binding|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear body|
|nuclear division|
|organelle fission|
|regulation of binding|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|protein localization to organelle|
|cell cycle process|
|chromosome organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.7|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.63|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.52|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.07|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.99|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.97|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.88|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.76|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.75|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.72|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.7|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.78|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.95|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.01|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.06|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.412|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.402|
|[[:human genes:r:rad21|RAD21]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 134/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|8/28|
|bone|7/26|
|breast|6/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|7/20|
|lung|6/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 73
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAU2 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>