MBIP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= MBIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBIP
  * **<color #00a2e8>Official Name</color>**: MAP3K12 binding inhibitory protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51562|51562]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS73|Q9NS73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609431|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inactivation of MAPK activity involved in osmosensory signaling pathway|
|molybdopterin synthase activity|
|osmosensory signaling pathway|
|molybdopterin cofactor biosynthetic process|
|prosthetic group metabolic process|
|molybdopterin cofactor metabolic process|
|Ada2/Gcn5/Ada3 transcription activator complex|
|inactivation of MAPK activity|
|protein kinase inhibitor activity|
|cellular response to osmotic stress|
|histone H3 acetylation|
|negative regulation of MAP kinase activity|
|response to osmotic stress|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|negative regulation of protein serine/threonine kinase activity|
|protein acetylation|
|negative regulation of MAPK cascade|
|protein acylation|
|cofactor biosynthetic process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|coenzyme metabolic process|
|negative regulation of transferase activity|
|peptidyl-lysine modification|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of MAP kinase activity|
|histone modification|
|covalent chromatin modification|
|negative regulation of protein phosphorylation|
|cofactor metabolic process|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|organophosphate biosynthetic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|chromatin organization|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.99|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.83|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.82|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.71|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.82|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.85|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.87|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.21|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zzz3|ZZZ3]]|0.48|
|[[:human genes:c:csrp2bp|CSRP2BP]]|0.461|
|[[:human genes:t:tada2a|TADA2A]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9603
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBIP Expression in NALM6 Cells: 4.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>