MC3R [The Human Chemical-Genetic Interaction Map Project]

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======= MC3R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MC3R
  * **<color #00a2e8>Official Name</color>**: melanocortin 3 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4159|4159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41968|P41968]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MC3R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MC3R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. {ECO:0000250|UniProtKB:P33033}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|homoiothermy|
|melanocyte-stimulating hormone receptor activity|
|melanocortin receptor activity|
|locomotor rhythm|
|neuropeptide binding|
|circadian behavior|
|rhythmic behavior|
|regulation of feeding behavior|
|temperature homeostasis|
|sodium ion homeostasis|
|peptide hormone binding|
|circadian regulation of gene expression|
|regulation of behavior|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of heart rate|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|monovalent inorganic cation homeostasis|
|circadian rhythm|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|locomotory behavior|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|rhythmic process|
|regulation of blood circulation|
|multicellular organismal homeostasis|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|chemical homeostasis|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|homeostatic process|
|intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3097
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MC3R Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>