MC4R [The Human Chemical-Genetic Interaction Map Project]

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======= MC4R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MC4R
  * **<color #00a2e8>Official Name</color>**: melanocortin 4 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4160|4160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32245|P32245]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MC4R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MC4R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:12646665, ECO:0000269|PubMed:25163632}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melanocyte-stimulating hormone receptor activity|
|melanocortin receptor activity|
|regulation of grooming behavior|
|negative regulation of feeding behavior|
|diet induced thermogenesis|
|negative regulation of behavior|
|positive regulation of bone remodeling|
|positive regulation of bone resorption|
|adaptive thermogenesis|
|neuropeptide binding|
|response to dietary excess|
|regulation of feeding behavior|
|positive regulation of tissue remodeling|
|insulin secretion|
|peptide hormone binding|
|regulation of bone resorption|
|regulation of bone remodeling|
|peptide hormone secretion|
|energy reserve metabolic process|
|regulation of behavior|
|hormone secretion|
|regulation of tissue remodeling|
|hormone transport|
|feeding behavior|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to insulin|
|energy derivation by oxidation of organic compounds|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|ubiquitin protein ligase binding|
|second-messenger-mediated signaling|
|response to peptide hormone|
|generation of precursor metabolites and energy|
|response to peptide|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|behavior|
|response to hormone|
|oxidation-reduction process|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7559
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MC4R Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>