MCM5 [The Human Chemical-Genetic Interaction Map Project]

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======= MCM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCM5
  * **<color #00a2e8>Official Name</color>**: minichromosome maintenance complex component 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4174|4174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33992|P33992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602696|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MCM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|
|pre-replicative complex assembly involved in cell cycle DNA replication|
|pre-replicative complex assembly|
|double-strand break repair via break-induced replication|
|MCM complex|
|single-stranded DNA helicase activity|
|3-5 DNA helicase activity|
|DNA replication origin binding|
|DNA replication initiation|
|nuclear DNA replication|
|cell cycle DNA replication|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|DNA duplex unwinding|
|G1/S transition of mitotic cell cycle|
|DNA geometric change|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|double-strand break repair|
|protein-DNA complex assembly|
|DNA replication|
|DNA recombination|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|DNA conformation change|
|DNA repair|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cell cycle|
|ATP binding|
|protein-containing complex assembly|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.38|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.32|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.23|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.18|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.16|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.06|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.06|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.96|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.95|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.92|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.9|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.89|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.86|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.8|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.76|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.72|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.7|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.83|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.98|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|3/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCM5 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>