ME2 [The Human Chemical-Genetic Interaction Map Project]

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======= ME2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ME2
  * **<color #00a2e8>Official Name</color>**: malic enzyme 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4200|4200]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23368|P23368]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ME2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ME2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|malic|
|Malic M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|malate dehydrogenase (decarboxylating) (NADP+) activity|
|malate dehydrogenase (decarboxylating) (NAD+) activity|
|malic enzyme activity|
|regulation of NADP metabolic process|
|oxaloacetate decarboxylase activity|
|malate metabolic process|
|tricarboxylic acid cycle|
|NAD binding|
|pyruvate metabolic process|
|electron transfer activity|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|cellular respiration|
|electron transport chain|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.28|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.7|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.74|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.75|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.77|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.79|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.82|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.9|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.9|
|[[:results:exp302|35°C R06 exp302]]|1.96|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.03|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.06|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.08|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.12|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.14|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.16|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.19|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.2|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.35|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.35|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.48|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.57|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.61|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.61|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|3|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.27|
|[[:results:exp224|CB-839 10μM R05 exp224]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ME2 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>