MED14 [The Human Chemical-Genetic Interaction Map Project]

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======= MED14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED14
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9282|9282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60244|O60244]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core mediator complex|
|vitamin D receptor binding|
|mediator complex|
|nuclear receptor transcription coactivator activity|
|transcription coregulator activity|
|stem cell population maintenance|
|maintenance of cell number|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.02|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.8|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.77|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.79|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.84|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.86|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.86|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.9|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.99|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd3|CBWD3]]|0.526|
|[[:human genes:r:rps2|RPS2]]|0.519|
|[[:human genes:t:tyms|TYMS]]|0.513|
|[[:human genes:c:chd4|CHD4]]|0.509|
|[[:human genes:p:psmb4|PSMB4]]|0.506|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.506|
|[[:human genes:p:polr2j3|POLR2J3]]|0.505|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.503|
|[[:human genes:c:copa|COPA]]|0.502|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.491|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.488|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.488|
|[[:human genes:p:psmc1|PSMC1]]|0.483|
|[[:human genes:n:nupl1|NUPL1]]|0.483|
|[[:human genes:p:psmc6|PSMC6]]|0.481|
|[[:human genes:c:cbwd5|CBWD5]]|0.48|
|[[:human genes:c:cbwd6|CBWD6]]|0.479|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.479|
|[[:human genes:t:ticrr|TICRR]]|0.476|
|[[:human genes:c:copb1|COPB1]]|0.474|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.47|
|[[:human genes:s:supt6h|SUPT6H]]|0.469|
|[[:human genes:n:npipb5|NPIPB5]]|0.469|
|[[:human genes:c:ccna2|CCNA2]]|0.464|
|[[:human genes:m:med17|MED17]]|0.461|
|[[:human genes:p:pan2|PAN2]]|0.461|
|[[:human genes:d:disp2|DISP2]]|0.458|
|[[:human genes:r:ranbp2|RANBP2]]|0.457|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.457|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.455|
|[[:human genes:a:aqr|AQR]]|0.454|
|[[:human genes:s:smg1|SMG1]]|0.454|
|[[:human genes:t:tfip11|TFIP11]]|0.452|
|[[:human genes:c:cactin|CACTIN]]|0.451|
|[[:human genes:z:zfand5|ZFAND5]]|0.45|
|[[:human genes:o:osbp|OSBP]]|0.45|
|[[:human genes:z:znf830|ZNF830]]|0.45|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.447|
|[[:human genes:s:slc38a7|SLC38A7]]|0.447|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.446|
|[[:human genes:a:ankle2|ANKLE2]]|0.445|
|[[:human genes:a:aatf|AATF]]|0.444|
|[[:human genes:a:aamp|AAMP]]|0.443|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.443|
|[[:human genes:v:vps52|VPS52]]|0.442|
|[[:human genes:t:tceb3c|TCEB3C]]|0.44|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.438|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.438|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.437|
|[[:human genes:p:prim1|PRIM1]]|0.437|
|[[:human genes:d:dtl|DTL]]|0.437|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.437|
|[[:human genes:k:kctd17|KCTD17]]|0.435|
|[[:human genes:c:chmp2a|CHMP2A]]|0.435|
|[[:human genes:p:psmb1|PSMB1]]|0.434|
|[[:human genes:g:gid4|GID4]]|0.433|
|[[:human genes:p:psmb2|PSMB2]]|0.432|
|[[:human genes:t:ttc1|TTC1]]|0.431|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.431|
|[[:human genes:r:rpl35|RPL35]]|0.429|
|[[:human genes:n:nup205|NUP205]]|0.429|
|[[:human genes:m:med29|MED29]]|0.428|
|[[:human genes:u:upf1|UPF1]]|0.428|
|[[:human genes:p:polr2j|POLR2J]]|0.427|
|[[:human genes:s:syt9|SYT9]]|0.427|
|[[:human genes:l:lrr1|LRR1]]|0.426|
|[[:human genes:m:mt1e|MT1E]]|0.426|
|[[:human genes:n:nop16|NOP16]]|0.426|
|[[:human genes:h:hap1|HAP1]]|0.426|
|[[:human genes:t:twistnb|TWISTNB]]|0.423|
|[[:human genes:d:ddt|DDT]]|0.423|
|[[:human genes:g:gprin2|GPRIN2]]|0.422|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:a:akirin2|AKIRIN2]]|0.421|
|[[:human genes:n:nol12|NOL12]]|0.42|
|[[:human genes:p:psmd11|PSMD11]]|0.42|
|[[:human genes:s:slc4a1|SLC4A1]]|0.419|
|[[:human genes:f:fcn2|FCN2]]|0.419|
|[[:human genes:n:ncbp1|NCBP1]]|0.419|
|[[:human genes:r:rbbp5|RBBP5]]|0.418|
|[[:human genes:m:myb|MYB]]|0.418|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:u:utp3|UTP3]]|0.417|
|[[:human genes:k:kmt2a|KMT2A]]|0.417|
|[[:human genes:o:ogfr|OGFR]]|0.416|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.415|
|[[:human genes:t:tsg101|TSG101]]|0.414|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.413|
|[[:human genes:t:timeless|TIMELESS]]|0.413|
|[[:human genes:d:ddtl|DDTL]]|0.413|
|[[:human genes:f:fbxo5|FBXO5]]|0.412|
|[[:human genes:r:rfxank|RFXANK]]|0.411|
|[[:human genes:e:egr2|EGR2]]|0.41|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.408|
|[[:human genes:s:sfpq|SFPQ]]|0.407|
|[[:human genes:z:znf541|ZNF541]]|0.406|
|[[:human genes:m:myo1h|MYO1H]]|0.406|
|[[:human genes:m:mtch2|MTCH2]]|0.406|
|[[:human genes:m:morc2|MORC2]]|0.406|
|[[:human genes:c:copz1|COPZ1]]|0.405|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.405|
|[[:human genes:s:snip1|SNIP1]]|0.405|
|[[:human genes:s:ssh2|SSH2]]|0.405|
|[[:human genes:h:h3f3a|H3F3A]]|0.404|
|[[:human genes:t:tpx2|TPX2]]|0.404|
|[[:human genes:p:pcf11|PCF11]]|0.403|
|[[:human genes:c:c14orf93|C14orf93]]|0.403|
|[[:human genes:p:psmd7|PSMD7]]|0.403|
|[[:human genes:n:napa|NAPA]]|0.402|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:n:nol8|NOL8]]|0.402|
|[[:human genes:a:apc2|APC2]]|0.401|
|[[:human genes:p:psmd13|PSMD13]]|0.401|
|[[:human genes:t:taf12|TAF12]]|0.401|
|[[:human genes:p:psmc2|PSMC2]]|0.401|
|[[:human genes:p:pan3|PAN3]]|0.4|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 322/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|21/26|
|bone|14/25|
|breast|11/30|
|central nervous system|17/49|
|cervix|0/4|
|colorectal|6/17|
|esophagus|7/11|
|fibroblast|1/1|
|gastric|4/14|
|kidney|3/18|
|liver|6/19|
|lung|28/72|
|lymphocyte|10/14|
|ovary|15/25|
|pancreas|11/22|
|peripheral nervous system|11/15|
|plasma cell|10/12|
|prostate|1/1|
|skin|9/20|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|9/28|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 863
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED14 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>