MED15 [The Human Chemical-Genetic Interaction Map Project]

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======= MED15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED15
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51586|51586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RN5|Q96RN5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607372|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med15|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mediator complex|
|transcription coregulator activity|
|stem cell population maintenance|
|maintenance of cell number|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.9|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.92|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.31|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd6|CBWD6]]|0.464|
|[[:human genes:f:fam25b|FAM25B]]|0.46|
|[[:human genes:c:cbwd3|CBWD3]]|0.457|
|[[:human genes:c:chd4|CHD4]]|0.45|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.45|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.449|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.449|
|[[:human genes:p:polr2d|POLR2D]]|0.441|
|[[:human genes:r:rad21|RAD21]]|0.439|
|[[:human genes:h:h3f3a|H3F3A]]|0.429|
|[[:human genes:e:exosc5|EXOSC5]]|0.424|
|[[:human genes:m:myb|MYB]]|0.421|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:s:supt5h|SUPT5H]]|0.42|
|[[:human genes:t:timeless|TIMELESS]]|0.419|
|[[:human genes:c:cbwd5|CBWD5]]|0.419|
|[[:human genes:p:plk1|PLK1]]|0.416|
|[[:human genes:t:twistnb|TWISTNB]]|0.416|
|[[:human genes:p:pola1|POLA1]]|0.415|
|[[:human genes:p:polr2j3|POLR2J3]]|0.409|
|[[:human genes:c:c14orf93|C14orf93]]|0.409|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:a:aamp|AAMP]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.402|
|[[:human genes:n:numa1|NUMA1]]|0.401|
|[[:human genes:r:rnpc3|RNPC3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/14|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1635
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED15 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>