MED23 [The Human Chemical-Genetic Interaction Map Project]

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======= MED23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED23
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9439|9439]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULK4|Q9ULK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605042|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med23|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mediator complex|
|transcription initiation from RNA polymerase II promoter|
|transcription factor complex|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.76|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.76|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.94|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.98|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.04|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.05|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.14|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.31|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.39|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.4|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.41|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.43|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.62|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.88|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mllt1|MLLT1]]|0.654|
|[[:human genes:c:ccdc101|CCDC101]]|0.622|
|[[:human genes:z:znf592|ZNF592]]|0.619|
|[[:human genes:m:med16|MED16]]|0.597|
|[[:human genes:t:tti2|TTI2]]|0.595|
|[[:human genes:r:rptor|RPTOR]]|0.571|
|[[:human genes:f:fbxo11|FBXO11]]|0.557|
|[[:human genes:w:wdr24|WDR24]]|0.556|
|[[:human genes:c:cbfb|CBFB]]|0.556|
|[[:human genes:a:aars|AARS]]|0.555|
|[[:human genes:t:taf6l|TAF6L]]|0.552|
|[[:human genes:f:fli1|FLI1]]|0.548|
|[[:human genes:g:gnb1l|GNB1L]]|0.544|
|[[:human genes:t:tle4|TLE4]]|0.542|
|[[:human genes:t:thoc6|THOC6]]|0.528|
|[[:human genes:r:rnmt|RNMT]]|0.526|
|[[:human genes:t:trim28|TRIM28]]|0.526|
|[[:human genes:t:taf5l|TAF5L]]|0.522|
|[[:human genes:t:tada1|TADA1]]|0.515|
|[[:human genes:o:otud5|OTUD5]]|0.513|
|[[:human genes:m:mtor|MTOR]]|0.508|
|[[:human genes:a:atf7ip|ATF7IP]]|0.503|
|[[:human genes:t:tti1|TTI1]]|0.501|
|[[:human genes:m:med13|MED13]]|0.501|
|[[:human genes:m:med13l|MED13L]]|0.5|
|[[:human genes:s:supt7l|SUPT7L]]|0.495|
|[[:human genes:c:cbx3|CBX3]]|0.494|
|[[:human genes:i:id3|ID3]]|0.494|
|[[:human genes:t:trip12|TRIP12]]|0.493|
|[[:human genes:b:brpf1|BRPF1]]|0.491|
|[[:human genes:p:pelo|PELO]]|0.49|
|[[:human genes:t:telo2|TELO2]]|0.489|
|[[:human genes:u:ube3a|UBE3A]]|0.488|
|[[:human genes:d:dohh|DOHH]]|0.484|
|[[:human genes:v:vmp1|VMP1]]|0.484|
|[[:human genes:e:eif4e|EIF4E]]|0.482|
|[[:human genes:t:thg1l|THG1L]]|0.478|
|[[:human genes:d:dpagt1|DPAGT1]]|0.477|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.477|
|[[:human genes:b:btaf1|BTAF1]]|0.474|
|[[:human genes:u:ube2g1|UBE2G1]]|0.473|
|[[:human genes:b:bap1|BAP1]]|0.47|
|[[:human genes:t:trim33|TRIM33]]|0.467|
|[[:human genes:u:uhrf1|UHRF1]]|0.466|
|[[:human genes:s:spcs3|SPCS3]]|0.462|
|[[:human genes:m:max|MAX]]|0.462|
|[[:human genes:m:mapk14|MAPK14]]|0.462|
|[[:human genes:t:triap1|TRIAP1]]|0.461|
|[[:human genes:u:ubr5|UBR5]]|0.46|
|[[:human genes:t:tmem41b|TMEM41B]]|0.46|
|[[:human genes:c:csnk2b|CSNK2B]]|0.457|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.455|
|[[:human genes:p:pmm2|PMM2]]|0.455|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.452|
|[[:human genes:u:usp22|USP22]]|0.452|
|[[:human genes:n:nae1|NAE1]]|0.45|
|[[:human genes:d:dcaf5|DCAF5]]|0.449|
|[[:human genes:m:maml1|MAML1]]|0.443|
|[[:human genes:v:vhl|VHL]]|0.44|
|[[:human genes:t:tada2b|TADA2B]]|0.44|
|[[:human genes:g:gmppb|GMPPB]]|0.439|
|[[:human genes:n:nsd1|NSD1]]|0.439|
|[[:human genes:g:gfpt1|GFPT1]]|0.437|
|[[:human genes:m:meaf6|MEAF6]]|0.436|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.436|
|[[:human genes:p:polr3h|POLR3H]]|0.435|
|[[:human genes:s:slc35b1|SLC35B1]]|0.435|
|[[:human genes:w:wdr59|WDR59]]|0.435|
|[[:human genes:t:tp53|TP53]]|0.434|
|[[:human genes:s:smarcd1|SMARCD1]]|0.433|
|[[:human genes:a:alg13|ALG13]]|0.432|
|[[:human genes:t:trmt10a|TRMT10A]]|0.432|
|[[:human genes:t:tsen54|TSEN54]]|0.431|
|[[:human genes:a:alg1|ALG1]]|0.431|
|[[:human genes:t:trnt1|TRNT1]]|0.429|
|[[:human genes:x:xpot|XPOT]]|0.429|
|[[:human genes:l:lsmd1|LSMD1]]|0.426|
|[[:human genes:z:zbtb44|ZBTB44]]|0.424|
|[[:human genes:s:sp3|SP3]]|0.42|
|[[:human genes:b:brd9|BRD9]]|0.418|
|[[:human genes:r:rtcb|RTCB]]|0.416|
|[[:human genes:z:zfx|ZFX]]|0.416|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.415|
|[[:human genes:l:lsm11|LSM11]]|0.414|
|[[:human genes:h:hdac8|HDAC8]]|0.412|
|[[:human genes:p:patz1|PATZ1]]|0.41|
|[[:human genes:u:uap1|UAP1]]|0.41|
|[[:human genes:d:dr1|DR1]]|0.409|
|[[:human genes:s:supt20h|SUPT20H]]|0.408|
|[[:human genes:m:mef2c|MEF2C]]|0.408|
|[[:human genes:z:znf608|ZNF608]]|0.407|
|[[:human genes:t:tceb3|TCEB3]]|0.407|
|[[:human genes:x:xpo6|XPO6]]|0.406|
|[[:human genes:e:exoc4|EXOC4]]|0.404|
|[[:human genes:p:pax5|PAX5]]|0.404|
|[[:human genes:u:ube2l3|UBE2L3]]|0.404|
|[[:human genes:s:ssbp2|SSBP2]]|0.404|
|[[:human genes:d:dcaf7|DCAF7]]|0.403|
|[[:human genes:a:arih1|ARIH1]]|0.402|
|[[:human genes:a:asb7|ASB7]]|0.401|
|[[:human genes:d:dhx29|DHX29]]|0.401|
|[[:human genes:a:actb|ACTB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 643
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED23 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>