MED29 [The Human Chemical-Genetic Interaction Map Project]

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======= MED29 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED29
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 29
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55588|55588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX70|Q9NX70]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED29&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED29|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15555573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med29|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mediator complex|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.516|
|[[:human genes:p:polr2j3|POLR2J3]]|0.513|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.511|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.49|
|[[:human genes:c:cbwd3|CBWD3]]|0.484|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.477|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.464|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.461|
|[[:human genes:a:aqr|AQR]]|0.459|
|[[:human genes:n:npipb5|NPIPB5]]|0.458|
|[[:human genes:c:cbwd5|CBWD5]]|0.456|
|[[:human genes:o:ogfr|OGFR]]|0.454|
|[[:human genes:p:pcf11|PCF11]]|0.452|
|[[:human genes:k:kif3c|KIF3C]]|0.447|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.446|
|[[:human genes:t:tceb3c|TCEB3C]]|0.445|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.443|
|[[:human genes:w:wdr43|WDR43]]|0.443|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.442|
|[[:human genes:p:psmc6|PSMC6]]|0.442|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.442|
|[[:human genes:c:c14orf93|C14orf93]]|0.442|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.442|
|[[:human genes:s:scaf1|SCAF1]]|0.441|
|[[:human genes:r:rps2|RPS2]]|0.438|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.437|
|[[:human genes:c:chaf1a|CHAF1A]]|0.437|
|[[:human genes:v:vasn|VASN]]|0.435|
|[[:human genes:s:sprr2b|SPRR2B]]|0.43|
|[[:human genes:m:med14|MED14]]|0.428|
|[[:human genes:m:med12|MED12]]|0.428|
|[[:human genes:s:s1pr4|S1PR4]]|0.426|
|[[:human genes:r:rfpl3|RFPL3]]|0.425|
|[[:human genes:s:ssh2|SSH2]]|0.424|
|[[:human genes:c:copb1|COPB1]]|0.424|
|[[:human genes:c:chd4|CHD4]]|0.423|
|[[:human genes:o:orc1|ORC1]]|0.422|
|[[:human genes:m:med17|MED17]]|0.422|
|[[:human genes:p:psmd3|PSMD3]]|0.421|
|[[:human genes:s:syt9|SYT9]]|0.417|
|[[:human genes:k:kmt2a|KMT2A]]|0.417|
|[[:human genes:p:polr2d|POLR2D]]|0.414|
|[[:human genes:c:ccdc94|CCDC94]]|0.413|
|[[:human genes:u:upf1|UPF1]]|0.413|
|[[:human genes:s:smg5|SMG5]]|0.412|
|[[:human genes:c:cdca3|CDCA3]]|0.41|
|[[:human genes:p:psmb4|PSMB4]]|0.41|
|[[:human genes:c:cbwd6|CBWD6]]|0.41|
|[[:human genes:m:myb|MYB]]|0.408|
|[[:human genes:h:hmgcr|HMGCR]]|0.407|
|[[:human genes:p:pan2|PAN2]]|0.406|
|[[:human genes:t:tfip11|TFIP11]]|0.405|
|[[:human genes:e:exosc5|EXOSC5]]|0.405|
|[[:human genes:s:sprr2a|SPRR2A]]|0.405|
|[[:human genes:y:ythdc1|YTHDC1]]|0.404|
|[[:human genes:p:psma6|PSMA6]]|0.404|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.403|
|[[:human genes:s:smg7|SMG7]]|0.403|
|[[:human genes:s:supt6h|SUPT6H]]|0.401|
|[[:human genes:r:rad51|RAD51]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED29 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>