MEIOB [The Human Chemical-Genetic Interaction Map Project]

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======= MEIOB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEIOB
  * **<color #00a2e8>Official Name</color>**: meiosis specific with OB-fold
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=254528|254528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N635|Q8N635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEIOB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEIOB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|single-stranded DNA 3-5 exodeoxyribonuclease activity|
|female meiosis I|
|resolution of meiotic recombination intermediates|
|meiotic chromosome separation|
|male meiosis I|
|female meiotic nuclear division|
|chromosome separation|
|synapsis|
|male meiotic nuclear division|
|reciprocal meiotic recombination|
|homologous recombination|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|meiosis I|
|meiosis I cell cycle process|
|chromosome|
|female gamete generation|
|meiotic nuclear division|
|meiotic cell cycle process|
|fertilization|
|double-strand break repair|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|chromatin binding|
|DNA repair|
|male gamete generation|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17792
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEIOB Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>