MERTK [The Human Chemical-Genetic Interaction Map Project]

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======= MERTK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MERTK
  * **<color #00a2e8>Official Name</color>**: MER proto-oncogene, tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10461|10461]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12866|Q12866]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MERTK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MERTK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604705|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:17005688}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rhabdomere|
|neutrophil clearance|
|natural killer cell differentiation|
|vagina development|
|neutrophil homeostasis|
|female genitalia development|
|Wnt-protein binding|
|protein kinase B signaling|
|apoptotic cell clearance|
|negative regulation of leukocyte apoptotic process|
|genitalia development|
|substrate adhesion-dependent cell spreading|
|transmembrane receptor protein tyrosine kinase activity|
|natural killer cell activation|
|photoreceptor outer segment|
|positive regulation of phagocytosis|
|leukocyte homeostasis|
|regulation of leukocyte apoptotic process|
|regulation of phagocytosis|
|tissue remodeling|
|myeloid cell homeostasis|
|female sex differentiation|
|platelet activation|
|retina development in camera-type eye|
|peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte activation|
|peptidyl-tyrosine modification|
|negative regulation of leukocyte activation|
|cell-substrate adhesion|
|negative regulation of cell activation|
|homeostasis of number of cells|
|receptor complex|
|lymphocyte differentiation|
|sex differentiation|
|negative regulation of cytokine production|
|blood coagulation|
|coagulation|
|hemostasis|
|camera-type eye development|
|phagocytosis|
|leukocyte differentiation|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|leukocyte migration|
|lymphocyte activation|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|negative regulation of immune system process|
|wound healing|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|spermatogenesis|
|sensory organ development|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|male gamete generation|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|developmental process involved in reproduction|
|gamete generation|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|protein phosphorylation|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|cell-cell signaling|
|secretion|
|negative regulation of multicellular organismal process|
|phosphorylation|
|locomotion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4373
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MERTK Expression in NALM6 Cells: 0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>