METTL1 [The Human Chemical-Genetic Interaction Map Project]

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======= METTL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: METTL1
  * **<color #00a2e8>Official Name</color>**: methyltransferase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4234|4234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBP6|Q9UBP6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=METTL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20METTL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604466|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:12403464}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA (guanine-N7)-methylation|
|tRNA (guanine-N7-)-methyltransferase activity|
|RNA (guanine-N7)-methylation|
|tRNA methylation|
|tRNA binding|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.7|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.72|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.81|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.82|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.82|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.83|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.84|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.86|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.88|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.9|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.91|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.92|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.96|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.96|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.97|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.02|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.12|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.14|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.14|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.16|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.2|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.2|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.21|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.33|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.4|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.44|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.46|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.49|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.5|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.63|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trmt61a|TRMT61A]]|0.596|
|[[:human genes:p:pmvk|PMVK]]|0.57|
|[[:human genes:p:prim1|PRIM1]]|0.53|
|[[:human genes:p:ppcdc|PPCDC]]|0.529|
|[[:human genes:d:dnlz|DNLZ]]|0.506|
|[[:human genes:w:wdr4|WDR4]]|0.493|
|[[:human genes:i:iba57|IBA57]]|0.492|
|[[:human genes:n:nars2|NARS2]]|0.462|
|[[:human genes:p:pet112|PET112]]|0.451|
|[[:human genes:p:pgm3|PGM3]]|0.446|
|[[:human genes:m:mipep|MIPEP]]|0.429|
|[[:human genes:t:trmt6|TRMT6]]|0.427|
|[[:human genes:a:aars2|AARS2]]|0.425|
|[[:human genes:p:ppa1|PPA1]]|0.422|
|[[:human genes:g:gnpnat1|GNPNAT1]]|0.422|
|[[:human genes:l:lars2|LARS2]]|0.416|
|[[:human genes:a:adat3|ADAT3]]|0.411|
|[[:human genes:y:yars2|YARS2]]|0.409|
|[[:human genes:a:adat2|ADAT2]]|0.407|
|[[:human genes:p:pars2|PARS2]]|0.405|
|[[:human genes:d:dap3|DAP3]]|0.404|
|[[:human genes:m:mrpl23|MRPL23]]|0.404|
|[[:human genes:n:nsun4|NSUN4]]|0.403|
|[[:human genes:m:mrps5|MRPS5]]|0.4|
|[[:human genes:t:tars2|TARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 143/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|7/28|
|bone|5/26|
|breast|2/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|5/21|
|liver|5/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|9/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='METTL1 Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>