METTL20 [The Human Chemical-Genetic Interaction Map Project]

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======= METTL20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETFBKMT
  * **<color #00a2e8>Official Name</color>**: electron transfer flavoprotein subunit beta lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=254013|254013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXQ9|Q8IXQ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=METTL20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20METTL20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615256|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). {ECO:0000269|PubMed:25023281, ECO:0000269|PubMed:25416781}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 16|
|PrmA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|negative regulation of electron transfer activity|
|negative regulation of fatty acid beta-oxidation|
|regulation of electron transfer activity|
|negative regulation of fatty acid oxidation|
|regulation of fatty acid beta-oxidation|
|negative regulation of lipid catabolic process|
|protein-lysine N-methyltransferase activity|
|negative regulation of oxidoreductase activity|
|negative regulation of fatty acid metabolic process|
|peptidyl-lysine trimethylation|
|regulation of fatty acid oxidation|
|regulation of lipid catabolic process|
|heat shock protein binding|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|peptidyl-lysine methylation|
|negative regulation of small molecule metabolic process|
|regulation of oxidoreductase activity|
|protein methylation|
|protein alkylation|
|regulation of generation of precursor metabolites and energy|
|regulation of cellular ketone metabolic process|
|macromolecule methylation|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|methylation|
|peptidyl-lysine modification|
|mitochondrial matrix|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|protein-containing complex|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|regulation of catabolic process|
|negative regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.28|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='METTL20 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>