MFRP [The Human Chemical-Genetic Interaction Map Project]

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======= MFRP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFRP
  * **<color #00a2e8>Official Name</color>**: membrane frizzled-related protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83552|83552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY79|Q9BY79]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFRP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFRP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606227|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in eye development. {ECO:0000269|PubMed:15976030}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|Ldl recept a|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eye photoreceptor cell development|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|photoreceptor cell differentiation|
|retina development in camera-type eye|
|eye morphogenesis|
|visual perception|
|sensory perception of light stimulus|
|sensory organ morphogenesis|
|camera-type eye development|
|apical plasma membrane|
|eye development|
|visual system development|
|sensory system development|
|sensory organ development|
|embryo development ending in birth or egg hatching|
|molecular function|
|neuron development|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|neuron differentiation|
|nervous system process|
|generation of neurons|
|neurogenesis|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.7|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.77|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.8|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.81|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.81|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.91|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.91|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.99|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.44|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc6a17|SLC6A17]]|0.45|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.445|
|[[:human genes:t:tceb3c|TCEB3C]]|0.438|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.437|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.424|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.409|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.409|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.409|
|[[:human genes:p:pbxip1|PBXIP1]]|0.401|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFRP Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>