MFSD12 [The Human Chemical-Genetic Interaction Map Project]

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======= MFSD12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFSD12
  * **<color #00a2e8>Official Name</color>**: major facilitator superfamily domain containing 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126321|126321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NUT3|Q6NUT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFSD12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFSD12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transporter activity|
|symporter activity|
|carbohydrate transport|
|lysosomal membrane|
|transmembrane transport|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.8|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.79|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.7|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.72|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.73|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.78|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.84|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.84|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.04|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.24|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.501|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.501|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.5|
|[[:human genes:c:ctage4|CTAGE4]]|0.483|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.482|
|[[:human genes:r:rpl35|RPL35]]|0.474|
|[[:human genes:t:tceb3c|TCEB3C]]|0.468|
|[[:human genes:d:dtl|DTL]]|0.467|
|[[:human genes:p:psmb4|PSMB4]]|0.466|
|[[:human genes:p:psma6|PSMA6]]|0.464|
|[[:human genes:c:col2a1|COL2A1]]|0.463|
|[[:human genes:c:copg1|COPG1]]|0.455|
|[[:human genes:n:nol10|NOL10]]|0.454|
|[[:human genes:c:chd4|CHD4]]|0.453|
|[[:human genes:t:tuba8|TUBA8]]|0.45|
|[[:human genes:r:rps12|RPS12]]|0.448|
|[[:human genes:z:znf830|ZNF830]]|0.443|
|[[:human genes:s:slc6a17|SLC6A17]]|0.443|
|[[:human genes:r:rpl6|RPL6]]|0.44|
|[[:human genes:c:cln6|CLN6]]|0.44|
|[[:human genes:p:psmb2|PSMB2]]|0.438|
|[[:human genes:o:orc6|ORC6]]|0.437|
|[[:human genes:s:snrnp70|SNRNP70]]|0.436|
|[[:human genes:c:cope|COPE]]|0.436|
|[[:human genes:c:chmp4b|CHMP4B]]|0.431|
|[[:human genes:o:osbp|OSBP]]|0.431|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.431|
|[[:human genes:w:wdr75|WDR75]]|0.431|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:r:rps7|RPS7]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.428|
|[[:human genes:s:sap30bp|SAP30BP]]|0.425|
|[[:human genes:t:tsg101|TSG101]]|0.423|
|[[:human genes:s:supt6h|SUPT6H]]|0.422|
|[[:human genes:v:vasn|VASN]]|0.422|
|[[:human genes:s:sec13|SEC13]]|0.42|
|[[:human genes:k:kctd17|KCTD17]]|0.417|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.417|
|[[:human genes:c:cdh24|CDH24]]|0.417|
|[[:human genes:s:sf3a3|SF3A3]]|0.417|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.416|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.416|
|[[:human genes:d:ddtl|DDTL]]|0.416|
|[[:human genes:a:aamp|AAMP]]|0.416|
|[[:human genes:n:nup205|NUP205]]|0.415|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.415|
|[[:human genes:p:pan3|PAN3]]|0.414|
|[[:human genes:p:pan2|PAN2]]|0.414|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.414|
|[[:human genes:g:golga8j|GOLGA8J]]|0.413|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.412|
|[[:human genes:l:lrr1|LRR1]]|0.411|
|[[:human genes:t:twistnb|TWISTNB]]|0.41|
|[[:human genes:u:utp3|UTP3]]|0.41|
|[[:human genes:c:cbwd3|CBWD3]]|0.41|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.409|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.408|
|[[:human genes:p:psmb3|PSMB3]]|0.407|
|[[:human genes:e:exosc9|EXOSC9]]|0.407|
|[[:human genes:p:polr1a|POLR1A]]|0.407|
|[[:human genes:m:msh5|MSH5]]|0.406|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.406|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:p:polr2d|POLR2D]]|0.401|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFSD12 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>