MGAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MGAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MGAT1
  * **<color #00a2e8>Official Name</color>**: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4245|4245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26572|P26572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MGAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MGAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GNT-I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|
|UDP-N-acetylglucosamine catabolic process|
|nucleotide-sugar catabolic process|
|amino sugar catabolic process|
|UDP-N-acetylglucosamine metabolic process|
|acetylglucosaminyltransferase activity|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|nucleobase-containing small molecule catabolic process|
|extracellular vesicle|
|manganese ion binding|
|protein N-linked glycosylation|
|carbohydrate derivative catabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|glycoprotein metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|peptidyl-amino acid modification|
|embryo development|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.34|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.12|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.07|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.84|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.78|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.72|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.71|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.32|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.75|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|3.08|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|3.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:b3gnt2|B3GNT2]]|0.495|
|[[:human genes:m:mapkapk5|MAPKAPK5]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|3/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MGAT1 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>