MIER2 [The Human Chemical-Genetic Interaction Map Project]

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======= MIER2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIER2
  * **<color #00a2e8>Official Name</color>**: MIER family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54531|54531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N344|Q8N344]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIER2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIER2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase activity|
|RNA polymerase II repressing transcription factor binding|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|histone deacetylase binding|
|transcription corepressor activity|
|histone modification|
|covalent chromatin modification|
|protein-containing complex|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.24|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.99|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.81|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.77|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.77|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.76|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.72|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.7|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.88|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.97|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.03|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9896
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIER2 Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>