MINOS1 [The Human Chemical-Genetic Interaction Map Project]

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======= MINOS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MICOS10
  * **<color #00a2e8>Official Name</color>**: mitochondrial contact site and cristae organizing system subunit 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440574|440574]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TGZ0|Q5TGZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MINOS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MINOS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF543|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MICOS complex|
|molecular function|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.9|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.73|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.73|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.82|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.92|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.93|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.95|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.16|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.502|
|[[:human genes:f:ftsj2|FTSJ2]]|0.469|
|[[:human genes:l:lars2|LARS2]]|0.465|
|[[:human genes:r:rpusd4|RPUSD4]]|0.452|
|[[:human genes:q:qrsl1|QRSL1]]|0.45|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.445|
|[[:human genes:p:pars2|PARS2]]|0.445|
|[[:human genes:e:ears2|EARS2]]|0.443|
|[[:human genes:c:c12orf65|C12orf65]]|0.435|
|[[:human genes:t:tefm|TEFM]]|0.435|
|[[:human genes:t:tmem261|TMEM261]]|0.432|
|[[:human genes:m:mrpl21|MRPL21]]|0.432|
|[[:human genes:a:atp5d|ATP5D]]|0.43|
|[[:human genes:t:trmt10a|TRMT10A]]|0.424|
|[[:human genes:c:c19orf70|C19orf70]]|0.424|
|[[:human genes:c:coq4|COQ4]]|0.423|
|[[:human genes:p:pet112|PET112]]|0.422|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.421|
|[[:human genes:p:pdss1|PDSS1]]|0.419|
|[[:human genes:m:mrps21|MRPS21]]|0.417|
|[[:human genes:n:ndufb11|NDUFB11]]|0.412|
|[[:human genes:y:yars2|YARS2]]|0.412|
|[[:human genes:n:ndufa2|NDUFA2]]|0.409|
|[[:human genes:m:mrps5|MRPS5]]|0.407|
|[[:human genes:m:mrps11|MRPS11]]|0.407|
|[[:human genes:m:mrps24|MRPS24]]|0.406|
|[[:human genes:d:dap3|DAP3]]|0.405|
|[[:human genes:f:fastkd5|FASTKD5]]|0.405|
|[[:human genes:g:gfm2|GFM2]]|0.404|
|[[:human genes:c:coa6|COA6]]|0.403|
|[[:human genes:c:c10orf2|C10orf2]]|0.403|
|[[:human genes:s:sars2|SARS2]]|0.402|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.401|
|[[:human genes:c:c17orf89|C17orf89]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 109/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|9/28|
|bone|5/26|
|breast|8/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|0/21|
|liver|2/20|
|lung|9/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MINOS1 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>