MIS12 [The Human Chemical-Genetic Interaction Map Project]

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======= MIS12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIS12
  * **<color #00a2e8>Official Name</color>**: MIS12 kinetochore complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79003|79003]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H081|Q9H081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIS12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIS12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mis12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear MIS12/MIND complex|
|MIS12/MIND type complex|
|attachment of mitotic spindle microtubules to kinetochore|
|protein localization to kinetochore|
|kinetochore assembly|
|protein localization to chromosome, centromeric region|
|kinetochore organization|
|attachment of spindle microtubules to kinetochore|
|centromere complex assembly|
|mitotic metaphase plate congression|
|metaphase plate congression|
|protein localization to chromosome|
|establishment of chromosome localization|
|chromosome localization|
|condensed chromosome kinetochore|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|protein-DNA complex assembly|
|nuclear chromosome segregation|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|protein localization to organelle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cell cycle|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 127/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|5/28|
|bone|8/26|
|breast|7/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|4/20|
|lung|12/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|8/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIS12 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>