MIS18A [The Human Chemical-Genetic Interaction Map Project]

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======= MIS18A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIS18A
  * **<color #00a2e8>Official Name</color>**: MIS18 kinetochore protein A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54069|54069]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYP9|Q9NYP9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIS18A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIS18A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618137|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of DNA methylation|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|chromosome, centromeric region|
|ATP-dependent chromatin remodeling|
|chromatin|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|chromosome segregation|
|DNA conformation change|
|regulation of DNA metabolic process|
|cell division|
|chromatin organization|
|cellular protein-containing complex assembly|
|chromosome organization|
|cell cycle|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.91|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.91|
|[[:results:exp302|35°C R06 exp302]]|-1.83|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.77|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.492|
|[[:human genes:p:pmm2|PMM2]]|0.469|
|[[:human genes:o:oraov1|ORAOV1]]|0.458|
|[[:human genes:t:triap1|TRIAP1]]|0.439|
|[[:human genes:v:vezt|VEZT]]|0.436|
|[[:human genes:a:alg1|ALG1]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.432|
|[[:human genes:w:wdr82|WDR82]]|0.428|
|[[:human genes:a:alg2|ALG2]]|0.424|
|[[:human genes:d:dpagt1|DPAGT1]]|0.424|
|[[:human genes:g:gpn2|GPN2]]|0.422|
|[[:human genes:a:alg13|ALG13]]|0.422|
|[[:human genes:d:ddx55|DDX55]]|0.421|
|[[:human genes:p:ppcs|PPCS]]|0.419|
|[[:human genes:r:rfk|RFK]]|0.415|
|[[:human genes:s:slc25a26|SLC25A26]]|0.413|
|[[:human genes:g:gfpt1|GFPT1]]|0.411|
|[[:human genes:a:adsl|ADSL]]|0.41|
|[[:human genes:a:atic|ATIC]]|0.41|
|[[:human genes:t:tsen54|TSEN54]]|0.408|
|[[:human genes:p:pdpk1|PDPK1]]|0.407|
|[[:human genes:t:tbp|TBP]]|0.403|
|[[:human genes:g:gmppb|GMPPB]]|0.403|
|[[:human genes:o:oip5|OIP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIS18A Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>